5VZX

Crystal structure of crenezumab Fab

Replaces:  5KMV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (H, E)	Crenezumab Fab heavy chain	polymer	220	22997.6	2	UniProt (P0DOX5)	Homo sapiens	Immunoglobulin gamma-1 heavy chain NIE
2	B, D (L, I)	Crenezumab Fab light chain	polymer	219	24064.8	2	UniProt (Q0KKI6)	Homo sapiens
3	E, H, I, J, K... (H, L, E, I)	SULFATE ION	non-polymer		96.1	11	Chemie (SO4)
4	F, N (H, E)	2-(N-MORPHOLINO)-ETHANESULFONIC ACID	non-polymer		195.2	2	Chemie (MES)
5	G, O (L, I)	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	2	Chemie (EPE)
6	T, U, V, W (H, L, E, I)	water	water		18.0	134	Chemie (HOH)

Sequence modifications

H, E: 1 - 108 (PDB: 5VZX)
H, E: 109 - 221 (UniProt: P0DOX5)
L, I: 1 - 104 (PDB: 5VZX)
L, I: 105 - 214 (UniProt: Q0KKI6)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	94124.7
Non-Polymers*	Number of molecules	15
	Total formula weight	1923.8
All*	Total formula weight	96048.5

*Water molecules are not included.