5VZX

Crystal structure of crenezumab Fab

Replaces:  5KMV

Functional Information from GO Data

Chain	GOid	namespace	contents
I	0002250	biological_process	adaptive immune response
I	0002376	biological_process	immune system process
I	0005576	cellular_component	extracellular region
I	0005886	cellular_component	plasma membrane
I	0019814	cellular_component	immunoglobulin complex
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0005576	cellular_component	extracellular region
L	0005886	cellular_component	plasma membrane
L	0019814	cellular_component	immunoglobulin complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue SO4 H 301

Chain	Residue
H	THR107
H	THR108
H	PRO149
H	HOH402

---

site_id	AC2
Number of Residues	8
Details	binding site for residue MES H 302

Chain	Residue
L	HIS34
L	TYR36
L	SER91
H	GLY33
H	SER35
H	SER94
H	GLY95
H	ASP101

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EPE L 301

Chain	Residue
H	PRO14
H	ALA84
H	GLU85
L	TYR32
L	LYS50
L	SER91

---

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 L 302

Chain	Residue
I	ASP60
I	ARG61
I	ARG77
L	ASP60
L	ARG61
L	ARG77

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 L 303

Chain	Residue
L	PRO8
L	LEU9
L	SER10

---

site_id	AC6
Number of Residues	1
Details	binding site for residue SO4 L 304

Chain	Residue
L	ARG54

---

site_id	AC7
Number of Residues	2
Details	binding site for residue SO4 L 305

Chain	Residue
L	LYS103
L	ARG142

---

site_id	AC8
Number of Residues	1
Details	binding site for residue SO4 L 306

Chain	Residue
L	ARG211

---

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 E 301

Chain	Residue
E	THR107
E	THR108
E	PRO149

---

site_id	AD1
Number of Residues	8
Details	binding site for residue MES E 302

Chain	Residue
E	GLY33
E	SER35
E	SER94
E	GLY95
E	ASP101
I	HIS34
I	TYR36
I	TRP96

---

site_id	AD2
Number of Residues	6
Details	binding site for residue EPE I 301

Chain	Residue
E	PRO14
E	ALA84
E	GLU85
I	TYR32
I	LYS50
I	SER91

---

site_id	AD3
Number of Residues	3
Details	binding site for residue SO4 I 302

Chain	Residue
I	PRO8
I	LEU9
I	SER10

---

site_id	AD4
Number of Residues	1
Details	binding site for residue SO4 I 303

Chain	Residue
I	ARG54

---

site_id	AD5
Number of Residues	2
Details	binding site for residue SO4 I 304

Chain	Residue
I	LYS103
I	ARG142

---

site_id	AD6
Number of Residues	1
Details	binding site for residue SO4 I 305

Chain	Residue
I	ARG211

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR194-HIS200
L	TYR192-HIS198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	190
Details	Domain: {"description":"Ig-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	186
Details	Domain: {"description":"Ig-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Pyrrolidone carboxylic acid","evidences":[{"source":"PubMed","id":"826475","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---