5VZT
Crystal structure of the Skp1-FBXO31 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | S-phase kinase-associated protein 1 | polymer | 149 | 16827.1 | 2 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) | Homo sapiens (Human) | Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
| 2 | B, D (B, D) | F-box only protein 31 | polymer | 488 | 55730.1 | 2 | UniProt (Q5XUX0) Pfam (PF12937) Pfam (PF12014) | Homo sapiens (Human) | |
| 3 | E, K (B, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, L (B, D) | 2,3-DIHYDROXY-1,4-DITHIOBUTANE | non-polymer | 154.3 | 2 | Chemie (DTT) | |||
| 5 | G, H, I, J, M... (B, D) | PHOSPHATE ION | non-polymer | 95.0 | 8 | Chemie (PO4) | |||
| 6 | Q, R, S (A, B, D) | water | water | 18.0 | 82 | Chemie (HOH) |
Sequence modifications
A, C: 1001 - 1163 (UniProt: P63208)
B, D: 66 - 539 (UniProt: Q5XUX0)
| PDB | External Database | Details |
|---|---|---|
| Ala 1002 | Pro 2 | engineered mutation |
| - | Asp 38 | deletion |
| - | Glu 39 | deletion |
| - | Gly 40 | deletion |
| - | Asp 41 | deletion |
| - | Asp 42 | deletion |
| - | Asp 43 | deletion |
| - | Pro 70 | deletion |
| - | Pro 71 | deletion |
| - | Pro 72 | deletion |
| - | Glu 73 | deletion |
| - | Asp 74 | deletion |
| - | Asp 75 | deletion |
| - | Glu 76 | deletion |
| - | Asn 77 | deletion |
| Gly 1078 | Lys 78 | see remark 999 |
| Gly 1079 | Glu 79 | see remark 999 |
| Ser 1080 | Lys 80 | see remark 999 |
| Gly 1081 | Arg 81 | see remark 999 |
| PDB | External Database | Details |
|---|---|---|
| Met 52 | - | expression tag |
| Ala 53 | - | expression tag |
| Ser 54 | - | expression tag |
| Trp 55 | - | expression tag |
| Ser 56 | - | expression tag |
| His 57 | - | expression tag |
| Pro 58 | - | expression tag |
| Gln 59 | - | expression tag |
| Phe 60 | - | expression tag |
| Glu 61 | - | expression tag |
| Lys 62 | - | expression tag |
| Ser 63 | - | expression tag |
| Gly 64 | - | expression tag |
| Arg 65 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 145114.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1199.1 | |
| All* | Total formula weight | 146313.6 |
