5VQK

X-ray co-structure of nuclear receptor ROR-gammat Ligand Binding Domain with a inverse agonist and SRC2 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Nuclear receptor ROR-gamma, SRC2 chimera	polymer	280	32442.4	1	UniProt (P51449) Pfam (PF00104) UniProt (by SIFTS) (Q15596)	Homo sapiens (Human)	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma,RORgt
2	B (A)	1-(4-fluorophenyl)-7-methoxy-N-{[4-(methylsulfamoyl)phenyl]methyl}-1H-pyrazolo[3,4-c]pyridine-4-carboxamide	non-polymer		469.5	1	Chemie (9GV)
3	C (A)	water	water		18.0	11	Chemie (HOH)

Sequence modifications

A: 260 - 507 (UniProt: P51449)

PDB	External Database	Details
Met 244	-	initiating methionine
Gly 245	-	expression tag
Ser 246	-	expression tag
Ser 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
Leu 254	-	expression tag
Val 255	-	expression tag
Pro 256	-	expression tag
Arg 257	-	expression tag
Gly 258	-	expression tag
Ser 259	-	expression tag

A: 508 - 523 (PDB: 5VQK)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	32442.4
Non-Polymers*	Number of molecules	1
	Total formula weight	469.5
All*	Total formula weight	32911.9

*Water molecules are not included.