5VEO

Murine ectonucleotide pyrophosphatase / phosphodiesterase 5 (ENPP5, NPP5), inactive (T72A), in complex with AMP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5	polymer	416	47793.6	1	UniProt (Q9EQG7) Pfam (PF01663)	Mus musculus (Mouse)	NPP-5
2	B (B)	alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		910.8	1	In PDB GlyTouCan (G22768VO)
3	C (C)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		894.8	1	In PDB GlyTouCan (G42466VF)
4	D, E, F (A)	ZINC ION	non-polymer		65.4	3	Chemie (ZN)
5	G, H, I, J (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
6	K, L (A)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
7	M (A)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
8	N, O, P (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	3	Chemie (PEG)
9	Q, R (A)	ADENOSINE MONOPHOSPHATE	non-polymer		347.2	2	Chemie (AMP)
10	S (A)	water	water		18.0	476	Chemie (HOH)

Sequence modifications

A: 25 - 430 (UniProt: Q9EQG7)

PDB	External Database	Details
Asp 15	-	expression tag
Arg 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
His 20	-	expression tag
His 21	-	expression tag
His 22	-	expression tag
Lys 23	-	expression tag
Leu 24	-	expression tag
Ala 72	Thr 72	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	47793.6
Branched	Number of molecules	2
	Total formula weight	1805.6
Non-Polymers*	Number of molecules	15
	Total formula weight	2368.2
All*	Total formula weight	51967.4

*Water molecules are not included.