5VAD
Crystal structure of human Prolyl-tRNA synthetase (PRS) in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Bifunctional glutamate/proline--tRNA ligase | polymer | 516 | 58405.7 | 2 | UniProt (P07814) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) | Homo sapiens (Human) | Bifunctional aminoacyl-tRNA synthetase,Cell proliferation-inducing gene 32 protein,Glutamatyl-prolyl-tRNA synthetase |
| 2 | C, F (A, B) | 3-[(cyclohexanecarbonyl)amino]-N-(2,3-dihydro-1H-inden-2-yl)pyrazine-2-carboxamide | non-polymer | 364.4 | 2 | Chemie (91Y) | |||
| 3 | D, G (A, B) | PROLINE | non-polymer | 115.1 | 2 | Chemie (PRO) | |||
| 4 | E, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 142 | Chemie (HOH) |
Sequence modifications
A, B: 998 - 1512 (UniProt: P07814)
| PDB | External Database | Details |
|---|---|---|
| Gly 997 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 116811.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1090.0 | |
| All* | Total formula weight | 117901.3 |
