5VAD

Crystal structure of human Prolyl-tRNA synthetase (PRS) in complex with inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004827	molecular_function	proline-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006433	biological_process	prolyl-tRNA aminoacylation
B	0000166	molecular_function	nucleotide binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004827	molecular_function	proline-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006433	biological_process	prolyl-tRNA aminoacylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue 91Y A 1601

Chain	Residue
A	ARG1152
A	THR1240
A	THR1276
A	ARG1278
A	HOH1718
A	GLU1154
A	HIS1157
A	PHE1161
A	LEU1162
A	ARG1163
A	THR1164
A	PHE1167
A	GLN1237

---

site_id	AC2
Number of Residues	10
Details	binding site for residue PRO A 1602

Chain	Residue
A	THR1121
A	GLU1123
A	ARG1152
A	TRP1169
A	PHE1216
A	HIS1242
A	SER1272
A	TRP1273
A	GLY1274
A	HOH1723

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN A 1603

Chain	Residue
A	CYS1448
A	CYS1453
A	CYS1495
A	CYS1497

---

site_id	AC4
Number of Residues	13
Details	binding site for residue 91Y B 1601

Chain	Residue
B	ARG1152
B	GLU1154
B	LYS1156
B	PHE1161
B	LEU1162
B	ARG1163
B	THR1164
B	PHE1167
B	THR1240
B	GLY1274
B	THR1276
B	ARG1278
B	HOH1734

---

site_id	AC5
Number of Residues	8
Details	binding site for residue PRO B 1602

Chain	Residue
B	THR1121
B	GLU1123
B	ARG1152
B	GLU1171
B	PHE1216
B	HIS1242
B	TRP1273
B	GLY1274

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN B 1603

Chain	Residue
B	CYS1448
B	CYS1453
B	CYS1495
B	CYS1497

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29273753","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K86","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K86","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23263184","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24100331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29273753","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"37212275","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4HVC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K86","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K87","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4K88","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5V58","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y1W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7Y3S","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---