5V7P
Atomic structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine carboxyl methyltransferase), in complex with a monobody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein-S-isoprenylcysteine O-methyltransferase | polymer | 288 | 32857.2 | 1 | UniProt (D6WJ77) Pfam (PF04140) | Tribolium castaneum (Red flour beetle) | |
| 2 | B (D) | monobody | polymer | 95 | 10135.4 | 1 | synthetic construct | ||
| 3 | C (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (193) PubChem (13792) PubChem (189149) PubChem (439155) PubChem (5284331) PubChem (71170554) PubChem (13231890) PubChem (16760024) PubChem (25210495) PubChem (44361184) PubChem (177678424) PubChem (46936206) PubChem (21125603) PubChem (25203782) PubChem (52224400) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (6419189) PubChem (57544532) PubChem (59046843) PubChem (59170628) PubChem (164157219) PubChem (59576228) PubChem (66805708) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 4 | D, E, K (A) | UNDECANE | non-polymer | 156.3 | 3 | Chemie (UND) PubChem (14257) | |||
| 5 | F, G, H, I, J... (A) | DECANE | non-polymer | 142.3 | 11 | Chemie (D10) PubChem (15600) | |||
| 6 | AA, R, S, T, U... (A) | [(Z)-octadec-9-enyl] (2R)-2,3-bis(oxidanyl)propanoate | non-polymer | 356.5 | 10 | Chemie (MPG) PubChem (5168638) PubChem (6289863) PubChem (11681934) PubChem (17754086) PubChem (44201365) PubChem (46936801) PubChem (56987534) | |||
| 7 | BA, CA (A, D) | water | water | 18.0 | 92 | Chemie (HOH) |
Sequence modifications
A: 1 - 281 (UniProt: D6WJ77)
| PDB | External Database | Details |
|---|---|---|
| Ala 282 | - | expression tag |
| Ala 283 | - | expression tag |
| Glu 284 | - | expression tag |
| Gly 285 | - | expression tag |
| Glu 286 | - | expression tag |
| Glu 287 | - | expression tag |
| Phe 288 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 42992.5 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 5983.8 | |
| All* | Total formula weight | 48976.4 |
