5V7P

Atomic structure of the eukaryotic intramembrane Ras methyltransferase ICMT (isoprenylcysteine carboxyl methyltransferase), in complex with a monobody

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004671	molecular_function	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006481	biological_process	C-terminal protein methylation
A	0008168	molecular_function	methyltransferase activity
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue SAH A 301

Chain	Residue
A	ASN183
A	HIS209
A	PRO210
A	SER211
A	TYR212
A	GLU250
A	LEU254
A	HOH413
A	HOH415
A	HOH427
A	PHE184
A	ASN185
A	GLN189
A	HIS196
A	VAL197
A	LEU198
A	VAL199
A	TYR204

---

site_id	AC2
Number of Residues	1
Details	binding site for residue UND A 302

Chain	Residue
A	ILE112

---

site_id	AC3
Number of Residues	2
Details	binding site for residue UND A 303

Chain	Residue
A	MET25
A	HIS28

---

site_id	AC4
Number of Residues	1
Details	binding site for residue D10 A 304

Chain	Residue
A	TYR217

---

site_id	AC5
Number of Residues	5
Details	binding site for residue D10 A 305

Chain	Residue
A	TYR217
A	THR271
A	GLY272
A	ILE273
A	ILE276

---

site_id	AC6
Number of Residues	1
Details	binding site for residue D10 A 306

Chain	Residue
D	VAL1

---

site_id	AC7
Number of Residues	4
Details	binding site for residue D10 A 308

Chain	Residue
A	LEU71
A	MET99
A	TRP139
A	D10310

---

site_id	AC8
Number of Residues	2
Details	binding site for residue UND A 309

Chain	Residue
A	SER137
A	ILE144

---

site_id	AC9
Number of Residues	4
Details	binding site for residue D10 A 310

Chain	Residue
A	ILE81
A	D10308
A	D10311
A	MPG323

---

site_id	AD1
Number of Residues	1
Details	binding site for residue D10 A 311

Chain	Residue
A	D10310

---

site_id	AD2
Number of Residues	1
Details	binding site for residue D10 A 312

Chain	Residue
A	TRP157

---

site_id	AD3
Number of Residues	2
Details	binding site for residue D10 A 313

Chain	Residue
A	PHE148
A	PHE149

---

site_id	AD4
Number of Residues	2
Details	binding site for residue D10 A 314

Chain	Residue
A	PHE70
A	TYR131

---

site_id	AD5
Number of Residues	1
Details	binding site for residue D10 A 315

Chain	Residue
A	HIS127

---

site_id	AD6
Number of Residues	5
Details	binding site for residue MPG A 316

Chain	Residue
A	SER128
A	VAL171
D	TYR78
D	TYR79
D	HOH114

---

site_id	AD7
Number of Residues	5
Details	binding site for residue MPG A 317

Chain	Residue
A	LYS82
A	LEU83
A	GLN90
A	HIS156
A	ASN160

---

site_id	AD8
Number of Residues	9
Details	binding site for residue MPG A 318

Chain	Residue
A	PRO4
A	LYS7
A	ILE8
A	GLN11
A	PHE56
A	TYR57
D	ALA12
D	LEU19
D	HOH124

---

site_id	AD9
Number of Residues	5
Details	binding site for residue MPG A 319

Chain	Residue
A	MPG321
D	VAL1
D	ALA26
D	VAL27
D	TYR78

---

site_id	AE1
Number of Residues	7
Details	binding site for residue MPG A 320

Chain	Residue
A	GLY31
A	ILE32
A	THR33
A	VAL37
A	PHE216
A	ILE220
A	TRP240

---

site_id	AE2
Number of Residues	8
Details	binding site for residue MPG A 321

Chain	Residue
A	LEU178
A	THR179
A	HIS201
A	MPG319
A	MPG322
D	VAL1
D	SER2
D	SER3

---

site_id	AE3
Number of Residues	5
Details	binding site for residue MPG A 322

Chain	Residue
A	TYR30
A	LEU237
A	MET241
A	MPG321
D	PRO81

---

site_id	AE4
Number of Residues	5
Details	binding site for residue MPG A 323

Chain	Residue
A	THR33
A	THR39
A	TYR80
A	VAL84
A	D10310

---

site_id	AE5
Number of Residues	7
Details	binding site for residue MPG A 324

Chain	Residue
A	ALA234
A	LEU237
A	ILE23
A	PHE26
A	ASN27
A	TYR45
A	PRO233

---

site_id	AE6
Number of Residues	11
Details	binding site for residue MPG A 325

Chain	Residue
A	TYR95
A	MET99
A	ASN126
A	TYR131
A	TRP215
A	SER219
A	THR222
A	GLN223
A	TYR235
A	SER239
D	TRP80

---

Functional Information from PROSITE/UniProt

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GETGGNSP

Chain	Residue	Details
D	GLY37-PRO44

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	178
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"29342140","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"29342140","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	71
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"29342140","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29342140","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5V7P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5VG9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"29342140","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---