5UWX

Crystal Structure of Inosine 5'-monophosphate Dehydrogenase from Clostridium perfringens Complexed with IMP and P176

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase	polymer	363	38441.3	4	UniProt (A0A127ELD1) Pfam (PF00478)	Clostridium perfringens	IMPDH,IMPDH
2	E, I, M, Q (A, B, C, D)	N-{2-chloro-5-[({2-[3-(prop-1-en-2-yl)phenyl]propan-2-yl}carbamoyl)amino]phenyl}-alpha-D-ribofuranosylamine	non-polymer		476.0	4	Chemie (8L7)
3	F, J, N, R (A, B, C, D)	INOSINIC ACID	non-polymer		348.2	4	Chemie (IMP)
4	G, K, P, S (A, B, C, D)	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	4	Chemie (MPD)
5	H, O, T (A, C, D)	ACETIC ACID	non-polymer		60.1	3	Chemie (ACY)
6	L (B)	(4R)-2-METHYLPENTANE-2,4-DIOL	non-polymer		118.2	1	Chemie (MRD)
7	U, V, W, X (A, B, C, D)	water	water		18.0	477	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 88 (UniProt: A0A127ELD1)

PDB	External Database	Details
Ser -2	-	expression tag
Asn -1	-	expression tag
Ala 0	-	expression tag

A, B, C, D: 216 - 484 (UniProt: A0A127ELD1)

PDB	External Database	Details
Ser 89	-	linker
Gly 90	-	linker
Gly 91	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	153765.1
Non-Polymers*	Number of molecules	16
	Total formula weight	4067.7
All*	Total formula weight	157832.8

*Water molecules are not included.