5UN2

Crystal Structure of Mouse Cadherin-23 EC19-21 with non-syndromic deafness (DFNB12) associated mutation R2029W

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cadherin-23	polymer	344	37578.8	1	UniProt (Q99PF4) Pfam (PF00028) In PDB	Mus musculus (Mouse)	Otocadherin
2	A	CALCIUM ION	non-polymer		40.1	8	Chemie (CA)
3	A	POTASSIUM ION	non-polymer		39.1	2	Chemie (K)
4		water	water		18.0	59	Chemie (HOH)

Sequence modifications

A: 1932 - 2266 (UniProt: Q99PF4)

PDB	External Database	Details
Met 1931	-	initiating methionine
Trp 2006	Arg 2029	engineered mutation
Leu 2267	-	expression tag
Glu 2268	-	expression tag
His 2269	-	expression tag
His 2270	-	expression tag
His 2271	-	expression tag
His 2272	-	expression tag
His 2273	-	expression tag
His 2274	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	37578.8
Non-Polymers*	Number of molecules	10
	Total formula weight	398.8
All*	Total formula weight	37977.6

*Water molecules are not included.