5UMM

CRYSTAL STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH 12-MER PEPTIDE INHIBITOR M3

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	E3 ubiquitin-protein ligase Mdm2	polymer	85	10044.9	2	UniProt (Q00987) Pfam (PF02201)	Homo sapiens	Double minute 2 protein,Hdm2,Oncoprotein Mdm2,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2
2	B, D (B, D)	PEPTIDE INHIBITOR M3	polymer	12	1542.8	2		synthetic construct
3	E (D)	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
4	F, G, H, I (A, B, C, D)	water	water		18.0	73	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	23175.4
Non-Polymers*	Number of molecules	1
	Total formula weight	35.5
All*	Total formula weight	23210.8

*Water molecules are not included.