5UK5
Complex of Notch1(EGF8-12) bound to Jagged1(N-EGF3)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Neurogenic locus notch homolog protein 1 | polymer | 205 | 21777.0 | 1 | UniProt (Q07008) Pfam (PF07645) Pfam (PF12661) | Rattus norvegicus (Rat) | Notch 1 |
| 2 | B (B) | Protein jagged-1 | polymer | 318 | 35733.0 | 1 | UniProt (Q63722) Pfam (PF07657) Pfam (PF01414) Pfam (PF21700) Pfam (PF00008) | Rattus norvegicus (Rat) | Jagged1 |
| 3 | C (C) | alpha-D-xylopyranose-(1-3)-beta-D-glucopyranose | branched | 312.3 | 1 | In PDB GlyTouCan (G01629YL) | |||
| 4 | D, E, F (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 5 | G, K, M (A, B) | alpha-L-fucopyranose | non-polymer | 164.2 | 3 | Chemie (FUC) | |||
| 6 | H, I (A) | beta-D-glucopyranose | non-polymer | 180.2 | 2 | Chemie (BGC) | |||
| 7 | J, L (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 8 | N (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 9 | O, P (A, B) | water | water | 18.0 | 138 | Chemie (HOH) |
Sequence modifications
A: 295 - 488 (UniProt: Q07008)
B: 32 - 334 (UniProt: Q63722)
| PDB | External Database | Details |
|---|---|---|
| Asp 293 | - | expression tag |
| Pro 294 | - | expression tag |
| Ser 489 | - | expression tag |
| Gly 490 | - | expression tag |
| Arg 491 | - | expression tag |
| Leu 492 | - | expression tag |
| Glu 493 | - | expression tag |
| Val 494 | - | expression tag |
| Leu 495 | - | expression tag |
| Phe 496 | - | expression tag |
| Gln 497 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 28 | - | expression tag |
| Asp 29 | - | expression tag |
| Pro 30 | - | expression tag |
| Arg 31 | - | expression tag |
| Leu 32 | Ser 32 | engineered mutation |
| Gly 68 | Arg 68 | engineered mutation |
| Asn 72 | Asp 72 | engineered mutation |
| Arg 87 | Thr 87 | engineered mutation |
| Arg 182 | Gln 182 | engineered mutation |
| Ala 335 | - | expression tag |
| Ala 336 | - | expression tag |
| Ala 337 | - | expression tag |
| His 338 | - | expression tag |
| His 339 | - | expression tag |
| His 340 | - | expression tag |
| His 341 | - | expression tag |
| His 342 | - | expression tag |
| His 343 | - | expression tag |
| His 344 | - | expression tag |
| His 345 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57510.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 312.3 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1610.7 | |
| All* | Total formula weight | 59433.0 |
