5U8R
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin-like growth factor 1 receptor | polymer | 885 | 101085.5 | 1 | UniProt (P08069) Pfam (PF01030) Pfam (PF00757) | Homo sapiens (Human) | Insulin-like growth factor I receptor,IGF-I receptor |
| 2 | B (H) | Fv 24-60 heavy chain | polymer | 126 | 13948.5 | 1 | Mus musculus | ||
| 3 | C (L) | Fv 24-60 light chain | polymer | 108 | 11733.9 | 1 | Mus musculus | ||
| 4 | D, E (B, C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | F (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 6 | G, H (A) | D-MALATE | non-polymer | 134.1 | 2 | Chemie (MLT) | |||
| 7 | I, J, K, L (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
| 8 | M (H) | IMIDAZOLE | non-polymer | 69.1 | 1 | Chemie (IMD) |
Sequence modifications
A: 1 - 905 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| - | Thr 748 | deletion |
| - | Thr 749 | deletion |
| - | Met 750 | deletion |
| - | Ser 751 | deletion |
| - | Ser 752 | deletion |
| - | Arg 753 | deletion |
| - | Ser 754 | deletion |
| - | Arg 755 | deletion |
| - | Asn 756 | deletion |
| - | Thr 757 | deletion |
| - | Thr 758 | deletion |
| - | Ala 759 | deletion |
| - | Ala 760 | deletion |
| - | Asp 761 | deletion |
| - | Thr 762 | deletion |
| - | Tyr 763 | deletion |
| - | Asn 764 | deletion |
| - | Ile 765 | deletion |
| - | Thr 766 | deletion |
| - | Asp 767 | deletion |
| Ala 738 | Pro 768 | conflict |
| Gly 739 | Glu 769 | conflict |
| Asn 740 | Glu 770 | conflict |
| Asn 741 | Leu 771 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 126767.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1318.2 | |
| All* | Total formula weight | 128934.8 |
