5U8Q
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin-like growth factor 1 receptor | polymer | 885 | 101085.5 | 1 | UniProt (P08069) Pfam (PF01030) Pfam (PF00757) | Homo sapiens (Human) | Insulin-like growth factor I receptor,IGF-I receptor |
| 2 | B (B) | Insulin-like growth factor I | polymer | 70 | 7663.8 | 1 | UniProt (P05019) Pfam (PF00049) | Homo sapiens (Human) | IGF-I,Mechano growth factor,MGF,Somatomedin-C |
| 3 | C (H) | Fv 24-60 heavy chain | polymer | 126 | 13948.5 | 1 | Mus musculus | ||
| 4 | D (L) | Fv 24-60 light chain | polymer | 108 | 11733.9 | 1 | Mus musculus | ||
| 5 | E, G (C, E) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | F (D) | alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81874LD) | |||
| 7 | H, I (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 8 | J (A) | D-MALATE | non-polymer | 134.1 | 1 | Chemie (MLT) | |||
| 9 | K, L, M (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A: 1 - 905 (UniProt: P08069)
| PDB | External Database | Details |
|---|---|---|
| - | Thr 748 | deletion |
| - | Thr 749 | deletion |
| - | Met 750 | deletion |
| - | Ser 751 | deletion |
| - | Ser 752 | deletion |
| - | Arg 753 | deletion |
| - | Ser 754 | deletion |
| - | Arg 755 | deletion |
| - | Asn 756 | deletion |
| - | Thr 757 | deletion |
| - | Thr 758 | deletion |
| - | Ala 759 | deletion |
| - | Ala 760 | deletion |
| - | Asp 761 | deletion |
| - | Thr 762 | deletion |
| - | Tyr 763 | deletion |
| - | Asn 764 | deletion |
| - | Ile 765 | deletion |
| - | Thr 766 | deletion |
| - | Asp 767 | deletion |
| Ala 738 | Pro 768 | conflict |
| Gly 739 | Glu 769 | conflict |
| Asn 740 | Glu 770 | conflict |
| Asn 741 | Leu 771 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 134431.6 | |
| Branched | Number of molecules | 3 |
| Total formula weight | 1597.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 989.8 | |
| All* | Total formula weight | 137019.0 |
