5U8Q
Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Insulin-like growth factor 1 receptor | polymer | 885 | 101085.5 | 1 | UniProt (P08069) Pfam (PF01030) Pfam (PF00757) In PDB | Homo sapiens (Human) | Insulin-like growth factor I receptor,IGF-I receptor |
2 | B | Insulin-like growth factor I | polymer | 70 | 7663.8 | 1 | UniProt (P05019) Pfam (PF00049) In PDB | Homo sapiens (Human) | IGF-I,Mechano growth factor,MGF,Somatomedin-C |
3 | H | Fv 24-60 heavy chain | polymer | 126 | 13948.5 | 1 | Mus musculus | ||
4 | L | Fv 24-60 light chain | polymer | 108 | 11733.9 | 1 | Mus musculus | ||
5 | C, E | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
6 | D | alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81874LD) | |||
7 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
8 | A | D-MALATE | non-polymer | 134.1 | 1 | Chemie (MLT) | |||
9 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) |
Sequence modifications
A: 1 - 905 (UniProt: P08069)
PDB | External Database | Details |
---|---|---|
- | Thr 748 | deletion |
- | Thr 749 | deletion |
- | Met 750 | deletion |
- | Ser 751 | deletion |
- | Ser 752 | deletion |
- | Arg 753 | deletion |
- | Ser 754 | deletion |
- | Arg 755 | deletion |
- | Asn 756 | deletion |
- | Thr 757 | deletion |
- | Thr 758 | deletion |
- | Ala 759 | deletion |
- | Ala 760 | deletion |
- | Asp 761 | deletion |
- | Thr 762 | deletion |
- | Tyr 763 | deletion |
- | Asn 764 | deletion |
- | Ile 765 | deletion |
- | Thr 766 | deletion |
- | Asp 767 | deletion |
Ala 738 | Pro 768 | conflict |
Gly 739 | Glu 769 | conflict |
Asn 740 | Glu 770 | conflict |
Asn 741 | Leu 771 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 134431.6 | |
Branched | Number of molecules | 3 |
Total formula weight | 1597.5 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 989.8 | |
All* | Total formula weight | 137019.0 |