5U7Z

Human acid ceramidase (ASAH1, aCDase) self-activated

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Acid ceramidase	polymer	129	14865.2	2	UniProt (A8K0B6) Pfam (PF15508) UniProt (by SIFTS) (Q13510) In PDB	Homo sapiens (Human)
2	B, D	Acid ceramidase	polymer	255	29207.4	2	UniProt (A8K0B6) Pfam (PF02275) UniProt (by SIFTS) (Q13510) In PDB	Homo sapiens (Human)
3	E, F	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
4	A, B, C, D	SULFATE ION	non-polymer		96.1	13	Chemie (SO4)
5	B, D	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	5	Chemie (NAG)
6		water	water		18.0	33	Chemie (HOH)

Sequence modifications

A, C: 22 - 140 (UniProt: A8K0B6)

PDB	External Database	Details
Asp 12	-	expression tag
Arg 13	-	expression tag
His 14	-	expression tag
His 15	-	expression tag
His 16	-	expression tag
His 17	-	expression tag
His 18	-	expression tag
His 19	-	expression tag
Lys 20	-	expression tag
Leu 21	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	88145.2
Branched	Number of molecules	2
	Total formula weight	1173.1
Non-Polymers*	Number of molecules	18
	Total formula weight	2354.9
All*	Total formula weight	91673.1

*Water molecules are not included.