5U2H
Crystal structure of the ATP-gated P2X7 ion channel bound to ATP and allosteric antagonist A804598
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | P2X purinoceptor | polymer | 342 | 38716.2 | 2 | UniProt (G1M6C4) Pfam (PF00864) In PDB | Ailuropoda melanoleuca (Giant panda) | |
2 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
3 | A, B | N-cyano-N'-[(1R)-1-phenylethyl]-N''-quinolin-5-ylguanidine | non-polymer | 315.4 | 2 | Chemie (7S1) | |||
4 | B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
5 | B | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) |
Sequence modifications
A, B: 23 - 358 (UniProt: G1M6C4)
PDB | External Database | Details |
---|---|---|
Gly 21 | - | expression tag |
Ser 22 | - | expression tag |
Ala 35 | Val 36 | engineered mutation |
Ala 125 | Arg 126 | engineered mutation |
Lys 174 | Glu 175 | engineered mutation |
Ser 241 | Asn 242 | engineered mutation |
Ser 284 | Asn 285 | engineered mutation |
Ser 359 | - | expression tag |
Ala 360 | - | expression tag |
Ser 361 | - | expression tag |
Ser 362 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 77432.5 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1359.1 | |
All* | Total formula weight | 79640.4 |