5TZT

Crystal structure of human CD47 ECD bound to Fab of C47B161

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (B, L)	Light Chain of Fab C47B161	polymer	219	24141.0	2		Homo sapiens
2	B, D (A, H)	Heavy Chain of Fab C47B161	polymer	226	24311.2	2		Homo sapiens
3	E, F (C, D)	Leukocyte surface antigen CD47	polymer	129	14747.5	2	UniProt (Q08722) Pfam (PF08204)	Homo sapiens (Human)	Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6
4	G, H, I, J, K (B, A, L, H)	GLYCEROL	non-polymer		92.1	5	Chemie (GOL)
5	L, M, N (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
6	O, P, Q, R, S... (B, A, L, H, C...)	water	water		18.0	118	Chemie (HOH)

Sequence modifications

C, D: 1 - 123 (UniProt: Q08722)

PDB	External Database	Details
Gly 15	Cys 33	engineered mutation
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag
His 128	-	expression tag
His 129	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	126399.4
Non-Polymers*	Number of molecules	8
	Total formula weight	1124.1
All*	Total formula weight	127523.5

*Water molecules are not included.