5TZT
Crystal structure of human CD47 ECD bound to Fab of C47B161
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, L | Light Chain of Fab C47B161 | polymer | 219 | 24141.0 | 2 | Homo sapiens | ||
2 | A, H | Heavy Chain of Fab C47B161 | polymer | 226 | 24311.2 | 2 | Homo sapiens | ||
3 | C, D | Leukocyte surface antigen CD47 | polymer | 129 | 14747.5 | 2 | UniProt (Q08722) Pfam (PF08204) In PDB | Homo sapiens (Human) | Antigenic surface determinant protein OA3,Integrin-associated protein,IAP,Protein MER6 |
4 | B, A, L, H | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
5 | C, D | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
6 | water | water | 18.0 | 118 | Chemie (HOH) |
Sequence modifications
C, D: 1 - 123 (UniProt: Q08722)
PDB | External Database | Details |
---|---|---|
Gly 15 | Cys 33 | engineered mutation |
His 124 | - | expression tag |
His 125 | - | expression tag |
His 126 | - | expression tag |
His 127 | - | expression tag |
His 128 | - | expression tag |
His 129 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 126399.4 | |
Non-Polymers* | Number of molecules | 8 |
Total formula weight | 1124.1 | |
All* | Total formula weight | 127523.5 |