5TL6
Crystal structure of SARS-CoV papain-like protease in complex with the C-terminal domain of human ISG15
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (B, D) | Replicase polyprotein 1ab | polymer | 319 | 35809.6 | 2 | UniProt (P0C6X7) Pfam (PF08715) | Human SARS coronavirus (SARS-CoV) | pp1ab,ORF1ab polyprotein |
| 2 | C, D (C, A) | Ubiquitin-like protein ISG15 | polymer | 79 | 8909.3 | 2 | UniProt (P05161) Pfam (PF00240) | Homo sapiens (Human) | Interferon-induced 15 kDa protein,Interferon-induced 17 kDa protein,IP17,Ubiquitin cross-reactive protein,hUCRP |
| 3 | E, G (B, D) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | H, I, J, K (B, D, C, A) | water | water | 18.0 | 131 | Chemie (HOH) |
Sequence modifications
B, D: 2 - 316 (UniProt: P0C6X7)
C, A: 80 - 157 (UniProt: P05161)
| PDB | External Database | Details |
|---|---|---|
| Met -2 | - | initiating methionine |
| Ala -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Met 1 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 79 | - | initiating methionine |
| Aye 157 | Gly 157 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 89437.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 226.9 | |
| All* | Total formula weight | 89664.7 |
