5TL6

Crystal structure of SARS-CoV papain-like protease in complex with the C-terminal domain of human ISG15

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0006508	biological_process	proteolysis
B	0008234	molecular_function	cysteine-type peptidase activity
D	0006508	biological_process	proteolysis
D	0008234	molecular_function	cysteine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN B 401

Chain	Residue
B	CYS190
B	CYS193
B	CYS225
B	CYS227

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site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 B 402

Chain	Residue
B	ASN14
B	ARG139
B	ASN147

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site_id	AC3
Number of Residues	4
Details	binding site for residue ZN D 401

Chain	Residue
D	CYS225
D	CYS227
D	CYS190
D	CYS193

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Interacts with activating enzyme => ECO:0000250

Chain	Residue	Details
C	ARG153
A	ARG153

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214

Chain	Residue	Details
C	AYE157
B	HIS273
A	AYE157
D	CYS112
D	HIS273
D	ASP287

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00444

Chain	Residue	Details
B	CYS190
B	CYS193
B	CYS225
B	CYS227
D	CYS190
D	CYS193
D	CYS225
D	CYS227

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

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site_id	MCSA2
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

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