5TEY
Human METTL3-METTL14 complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | N6-adenosine-methyltransferase 70 kDa subunit | polymer | 598 | 66735.3 | 1 | UniProt (Q86U44) Pfam (PF05063) In PDB | Homo sapiens (Human) | MT-A70,Methyltransferase-like protein 3 |
| 2 | B | N6-adenosine-methyltransferase subunit METTL14 | polymer | 399 | 46417.1 | 1 | UniProt (Q9HCE5) Pfam (PF05063) In PDB | Homo sapiens (Human) | Methyltransferase-like protein 14 |
| 3 | A | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | A, B | UNKNOWN ATOM OR ION | non-polymer | 8 | Chemie (UNX) | ||||
| 7 | B | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 8 | water | water | 18.0 | 196 | Chemie (HOH) |
Sequence modifications
A: 1 - 580 (UniProt: Q86U44)
| PDB | External Database | Details |
|---|---|---|
| Met -17 | - | initiating methionine |
| His -16 | - | expression tag |
| His -15 | - | expression tag |
| His -14 | - | expression tag |
| His -13 | - | expression tag |
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| Ser -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Gly -8 | - | expression tag |
| Arg -7 | - | expression tag |
| Glu -6 | - | expression tag |
| Asn -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Tyr -3 | - | expression tag |
| Phe -2 | - | expression tag |
| Gln -1 | - | expression tag |
| Gly 0 | - | expression tag |
| Lys 568 | Arg 568 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 113152.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 548.9 | |
| All* | Total formula weight | 113701.2 |
