5TEY
Human METTL3-METTL14 complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000398 | biological_process | mRNA splicing, via spliceosome |
| A | 0001510 | biological_process | RNA methylation |
| A | 0001734 | molecular_function | mRNA m(6)A methyltransferase activity |
| A | 0002376 | biological_process | immune system process |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006397 | biological_process | mRNA processing |
| A | 0006974 | biological_process | DNA damage response |
| A | 0007283 | biological_process | spermatogenesis |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008173 | molecular_function | RNA methyltransferase activity |
| A | 0009048 | biological_process | dosage compensation by inactivation of X chromosome |
| A | 0016556 | biological_process | mRNA modification |
| A | 0016604 | cellular_component | nuclear body |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019827 | biological_process | stem cell population maintenance |
| A | 0021861 | biological_process | forebrain radial glial cell differentiation |
| A | 0030154 | biological_process | cell differentiation |
| A | 0031053 | biological_process | primary miRNA processing |
| A | 0032259 | biological_process | methylation |
| A | 0034644 | biological_process | cellular response to UV |
| A | 0036396 | cellular_component | RNA N6-methyladenosine methyltransferase complex |
| A | 0042063 | biological_process | gliogenesis |
| A | 0043489 | biological_process | RNA stabilization |
| A | 0045087 | biological_process | innate immune response |
| A | 0045580 | biological_process | regulation of T cell differentiation |
| A | 0045727 | biological_process | positive regulation of translation |
| A | 0045746 | biological_process | negative regulation of Notch signaling pathway |
| A | 0046982 | molecular_function | protein heterodimerization activity |
| A | 0048477 | biological_process | oogenesis |
| A | 0048511 | biological_process | rhythmic process |
| A | 0051445 | biological_process | regulation of meiotic cell cycle |
| A | 0060339 | biological_process | negative regulation of type I interferon-mediated signaling pathway |
| A | 0061157 | biological_process | mRNA destabilization |
| A | 0098508 | biological_process | endothelial to hematopoietic transition |
| A | 1902036 | biological_process | regulation of hematopoietic stem cell differentiation |
| A | 1903679 | biological_process | positive regulation of cap-independent translational initiation |
| A | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| A | 1990931 | molecular_function | mRNA N6-methyladenosine dioxygenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue SAH A 601 |
| Chain | Residue |
| A | CYS376 |
| A | HIS512 |
| A | LYS513 |
| A | PHE534 |
| A | ARG536 |
| A | HIS538 |
| A | ASN539 |
| A | ASN549 |
| A | GLN550 |
| A | HOH729 |
| A | HOH736 |
| A | ASP377 |
| A | HOH760 |
| A | ILE378 |
| A | ASP395 |
| A | PRO397 |
| A | TYR406 |
| A | GLY407 |
| A | LEU409 |
| A | SER511 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 602 |
| Chain | Residue |
| A | GLU506 |
| A | HOH705 |
| A | HOH726 |
| A | HOH741 |
| A | HOH776 |
| B | ASN117 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 603 |
| Chain | Residue |
| A | ASN445 |
| A | ARG451 |
| A | HOH773 |
| B | ASP242 |
| B | ASN368 |
| B | HOH559 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue BME B 401 |
| Chain | Residue |
| A | HIS474 |
| A | TRP475 |
| A | LEU476 |
| B | CYS256 |
| B | GLU257 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Region: {"description":"Interaction with METTL14","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Region: {"description":"Gate loop 2","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27373337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27627798","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K7W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L6D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L6E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27373337","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K7U","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5K7W","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with METTL14","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 14 |
| Details | Region: {"description":"Interaction with METTL3","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | Region: {"description":"Positively charged region required for RNA-binding","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with METTL3","evidences":[{"source":"PubMed","id":"27281194","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IL0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5IL2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
