5TDF

TEV Cleaved Human ATP Citrate Lyase Bound to 4S hydroxycitrate

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	ATP-citrate synthase	polymer	431	47836.6	1	UniProt (P53396) Pfam (PF16114) In PDB	Homo sapiens (Human)	ATP-citrate (pro-S-)-lyase,ACL,Citrate cleavage enzyme
2	B	ATP-citrate synthase	polymer	324	35421.6	1	UniProt (P53396) Pfam (PF02629) Pfam (PF00549) In PDB	Homo sapiens (Human)	ATP-citrate (pro-S-)-lyase,ACL,Citrate cleavage enzyme
3	A	3-C-carboxy-2-deoxy-D-erythro-pentaric acid	non-polymer		208.1	1	Chemie (7A3)
4	A	ADENOSINE-5'-DIPHOSPHATE	non-polymer		427.2	1	Chemie (ADP)
5	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	A, B	GLYCEROL	non-polymer		92.1	6	Chemie (GOL)
7	A	ADENINE	non-polymer		135.1	1	Chemie (ADE)
8		water	water		18.0	821	Chemie (HOH)

Sequence modifications

A: 1 - 425 (UniProt: P53396)

PDB	External Database	Details
Glu 426	-	SEE REMARK 999
Asn 427	-	SEE REMARK 999
Leu 428	-	SEE REMARK 999
Tyr 429	-	SEE REMARK 999
Phe 430	-	SEE REMARK 999
Gln 431	-	SEE REMARK 999

B: 488 - 810 (UniProt: P53396)

PDB	External Database	Details
Ser 487	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83258.2
Non-Polymers*	Number of molecules	11
	Total formula weight	1371.6
All*	Total formula weight	84629.8

*Water molecules are not included.