5TDF

TEV Cleaved Human ATP Citrate Lyase Bound to 4S hydroxycitrate

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0003824	molecular_function	catalytic activity
B	0046912	molecular_function	acyltransferase activity, acyl groups converted into alkyl on transfer

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 7A3 A 901

Chain	Residue
A	SER308
A	HOH1041
A	HOH1104
A	HOH1223
A	HOH1328
B	NEP760
A	GLY309
A	SER343
A	ALA345
A	ASN346
A	PHE347
A	THR348
A	ARG379
A	HOH1012

---

site_id	AC2
Number of Residues	23
Details	binding site for residue ADP A 902

Chain	Residue
A	VAL56
A	LYS58
A	ARG65
A	ARG66
A	GLY67
A	PRO109
A	PHE110
A	VAL111
A	HIS113
A	GLU118
A	ASN203
A	PRO204
A	LEU215
A	ASP216
A	MG903
A	HOH1017
A	HOH1045
A	HOH1059
A	HOH1184
A	HOH1208
A	HOH1254
A	HOH1280
A	HOH1318

---

site_id	AC3
Number of Residues	5
Details	binding site for residue MG A 903

Chain	Residue
A	ASN203
A	ASP216
A	ADP902
A	HOH1254
A	HOH1318

---

site_id	AC4
Number of Residues	3
Details	binding site for residue GOL A 904

Chain	Residue
A	TYR124
A	LYS151
B	TYR517

---

site_id	AC5
Number of Residues	5
Details	binding site for residue GOL A 905

Chain	Residue
A	ARG33
A	THR35
A	THR38
A	ADE907
A	HOH1243

---

site_id	AC6
Number of Residues	7
Details	binding site for residue GOL A 906

Chain	Residue
A	ASP164
A	LYS167
A	HIS168
A	HOH1008
B	PRO654
B	ASP679
B	HOH1232

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ADE A 907

Chain	Residue
A	ASP39
A	ARG42
A	LEU43
A	GOL905
A	HOH1026

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MG B 901

Chain	Residue
A	HOH1012
A	HOH1033
A	HOH1223
B	NEP760
B	HOH1015
B	HOH1038

---

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL B 902

Chain	Residue
A	HIS410
B	ILE673
B	PHE790
B	ASP791
B	LEU793
B	GLY794
B	HOH1112
B	HOH1150

---

site_id	AD1
Number of Residues	8
Details	binding site for residue GOL B 903

Chain	Residue
A	LYS230
A	HOH1036
B	ARG576
B	PHE785
B	SER799
B	VAL800
B	ASP803
B	HOH1062

---

site_id	AD2
Number of Residues	6
Details	binding site for residue GOL B 904

Chain	Residue
B	GLN777
B	LYS780
B	PRO787
B	ARG788
B	HOH1012
B	HOH1068

---

Functional Information from PROSITE/UniProt

site_id	PS00399
Number of Residues	17
Details	SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GtcAtmfssevQFGHAG

Chain	Residue	Details
B	GLY746-GLY762

---

site_id	PS01216
Number of Residues	30
Details	SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGGMSnElnniisrttdGvyegVAIGGD

Chain	Residue	Details
B	SER661-ASP690

---

site_id	PS01217
Number of Residues	25
Details	SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GrIwtMvAGGGASvvysDtIcdl.GG

Chain	Residue	Details
A	GLY273-GLY297

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22102020","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20558738","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22102020","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20558738","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q91V92","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"PubMed","id":"1371749","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"23932781","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"23932781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"PubMed","id":"27664236","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23932781","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---