5TD5
Crystal Structure of Human APOBEC3B variant complexed with ssDNA
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | DNA dC->dU-editing enzyme APOBEC-3B | polymer | 190 | 22393.3 | 1 | UniProt (Q9UH17) Pfam (PF05240) In PDB | Homo sapiens (Human) | A3B,Phorbolin-1-related protein,Phorbolin-2/3 |
2 | C | DNA (5'-D(P*TP*TP*CP*AP*T)-3') | polymer | 7 | 2078.4 | 1 | Homo sapiens | ||
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | A, C | IODIDE ION | non-polymer | 126.9 | 9 | Chemie (IOD) | |||
5 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
6 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
7 | water | water | 18.0 | 98 | Chemie (HOH) |
Sequence modifications
A: 187 - 378 (UniProt: Q9UH17)
PDB | External Database | Details |
---|---|---|
Met 186 | - | expression tag |
Ser 200 | Phe 200 | engineered mutation |
- | Asp 205 | deletion |
- | Pro 206 | deletion |
- | Leu 207 | deletion |
Gly 205 | Val 208 | engineered mutation |
Ile 209 | Leu 209 | engineered mutation |
Gly 210 | Arg 210 | engineered mutation |
His 212 | Arg 212 | engineered mutation |
Lys 213 | Gln 213 | engineered mutation |
Ser 228 | Trp 228 | engineered mutation |
Lys 230 | Leu 230 | engineered mutation |
- | Ala 242 | deletion |
- | Lys 243 | deletion |
- | Asn 244 | deletion |
- | Leu 245 | deletion |
- | Leu 246 | deletion |
- | Cys 247 | deletion |
- | Gly 248 | deletion |
- | Phe 249 | deletion |
Ser 250 | Tyr 250 | engineered mutation |
Ala 255 | Glu 255 | engineered mutation |
Lys 308 | Phe 308 | engineered mutation |
Leu 379 | - | expression tag |
Glu 380 | - | expression tag |
His 381 | - | expression tag |
His 382 | - | expression tag |
His 383 | - | expression tag |
His 384 | - | expression tag |
His 385 | - | expression tag |
His 386 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 24471.7 | |
Non-Polymers* | Number of molecules | 18 |
Total formula weight | 1650.9 | |
All* | Total formula weight | 26122.6 |