5T89
Crystal structure of VEGF-A in complex with VEGFR-1 domains D1-6
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | V, W | Vascular endothelial growth factor A | polymer | 131 | 15195.2 | 2 | UniProt (P15692) Pfam (PF00341) In PDB | Homo sapiens (Human) | VEGF-A,Vascular permeability factor,VPF |
2 | X, Y | Vascular endothelial growth factor receptor 1 | polymer | 646 | 73374.2 | 2 | UniProt (P17948) Pfam (PF22854) Pfam (PF21339) Pfam (PF00047) Pfam (PF07679) Pfam (PF22971) Pfam (PF13927) In PDB | Homo sapiens (Human) | VEGFR-1,Fms-like tyrosine kinase 1,FLT-1,Tyrosine-protein kinase FRT,Tyrosine-protein kinase receptor FLT,FLT,Vascular permeability factor receptor |
3 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
4 | V, W, X, Y | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 19 | Chemie (NAG) |
Sequence modifications
V, W: 1 - 121 (UniProt: P15692)
X, Y: 27 - 656 (UniProt: P17948)
PDB | External Database | Details |
---|---|---|
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Asn 115 | Lys 141 | conflict |
PDB | External Database | Details |
---|---|---|
Asp 657 | - | expression tag |
Gln 658 | - | expression tag |
Glu 659 | - | expression tag |
Ala 660 | - | expression tag |
Ile 661 | - | expression tag |
Glu 662 | - | expression tag |
Gly 663 | - | expression tag |
Arg 664 | - | expression tag |
His 665 | - | expression tag |
His 666 | - | expression tag |
His 667 | - | expression tag |
His 668 | - | expression tag |
His 669 | - | expression tag |
His 670 | - | expression tag |
His 671 | - | expression tag |
His 672 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 177138.8 | |
Branched | Number of molecules | 2 |
Total formula weight | 848.8 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 4203.0 | |
All* | Total formula weight | 182190.5 |