5T89

Crystal structure of VEGF-A in complex with VEGFR-1 domains D1-6

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (V, W)	Vascular endothelial growth factor A	polymer	131	15195.2	2	UniProt (P15692) Pfam (PF00341)	Homo sapiens (Human)	VEGF-A,Vascular permeability factor,VPF
2	C, D (X, Y)	Vascular endothelial growth factor receptor 1	polymer	646	73374.2	2	UniProt (P17948) Pfam (PF22854) Pfam (PF21339) Pfam (PF00047) Pfam (PF07679) Pfam (PF22971) Pfam (PF13927)	Homo sapiens (Human)	VEGFR-1,Fms-like tyrosine kinase 1,FLT-1,Tyrosine-protein kinase FRT,Tyrosine-protein kinase receptor FLT,FLT,Vascular permeability factor receptor
3	E, F (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	G, H, I, J, K... (V, W, X, Y)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	19	Chemie (NAG)

Sequence modifications

V, W: 1 - 121 (UniProt: P15692)

PDB	External Database	Details
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
Asn 115	Lys 141	conflict

X, Y: 27 - 656 (UniProt: P17948)

PDB	External Database	Details
Asp 657	-	expression tag
Gln 658	-	expression tag
Glu 659	-	expression tag
Ala 660	-	expression tag
Ile 661	-	expression tag
Glu 662	-	expression tag
Gly 663	-	expression tag
Arg 664	-	expression tag
His 665	-	expression tag
His 666	-	expression tag
His 667	-	expression tag
His 668	-	expression tag
His 669	-	expression tag
His 670	-	expression tag
His 671	-	expression tag
His 672	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	177138.8
Branched	Number of molecules	2
	Total formula weight	848.8
Non-Polymers*	Number of molecules	19
	Total formula weight	4203.0
All*	Total formula weight	182190.5

*Water molecules are not included.