5T89

Crystal structure of VEGF-A in complex with VEGFR-1 domains D1-6

Functional Information from GO Data

Chain	GOid	namespace	contents
V	0008083	molecular_function	growth factor activity
V	0016020	cellular_component	membrane
W	0008083	molecular_function	growth factor activity
W	0016020	cellular_component	membrane
X	0005021	molecular_function	vascular endothelial growth factor receptor activity
X	0005524	molecular_function	ATP binding
X	0005886	cellular_component	plasma membrane
X	0006468	biological_process	protein phosphorylation
X	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
Y	0005021	molecular_function	vascular endothelial growth factor receptor activity
Y	0005524	molecular_function	ATP binding
Y	0005886	cellular_component	plasma membrane
Y	0006468	biological_process	protein phosphorylation
Y	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00249
Number of Residues	13
Details	PDGF_1 Platelet-derived growth factor (PDGF) family signature. PSCVplmRCGGCC

Chain	Residue	Details
V	PRO49-CYS61

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

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site_id	SWS_FT_FI2
Number of Residues	126
Details	Domain: {"description":"Ig-like C2-type 2"}

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site_id	SWS_FT_FI3
Number of Residues	172
Details	Domain: {"description":"Ig-like C2-type 4"}

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site_id	SWS_FT_FI4
Number of Residues	196
Details	Domain: {"description":"Ig-like C2-type 6"}

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site_id	SWS_FT_FI5
Number of Residues	22
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

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Residue

Details

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