5T5C

A Novel domain in human EXOG converts apoptotic endonuclease to DNA-repair enzyme

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Nuclease EXOG, mitochondrial	polymer	317	36275.2	2	UniProt (Q9Y2C4) Pfam (PF01223) Pfam (PF18026) In PDB	Homo sapiens (Human)	Endonuclease G-like 1,Endo G-like 1
2	C, E	DNA (5'-D(P*CP*TP*GP*AP*CP*GP*TP*GP*C)-3')	polymer	9	2731.8	2		DNA launch vector pDE-GFP2
3	D, F	DNA (5'-D(P*GP*CP*AP*CP*GP*TP*CP*AP*G)-3')	polymer	9	2740.8	2		DNA launch vector pDE-GFP2
4	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
5		water	water		18.0	270	Chemie (HOH)

Sequence modifications

A, B: 59 - 368 (UniProt: Q9Y2C4)

PDB	External Database	Details
Met 58	-	initiating methionine
Ala 140	His 140	engineered mutation
His 369	-	expression tag
His 370	-	expression tag
His 371	-	expression tag
His 372	-	expression tag
His 373	-	expression tag
His 374	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	83495.5
Non-Polymers*	Number of molecules	2
	Total formula weight	48.6
All*	Total formula weight	83544.1

*Water molecules are not included.