5Q0C
Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(4-methoxyphenyl)thiophen-2-yl]sulfonylurea and with fructose-2,6-diphosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Fructose-1,6-bisphosphatase isozyme 2 | polymer | 339 | 36798.1 | 8 | UniProt (O00757) Pfam (PF00316) Pfam (PF18913) | Homo sapiens (Human) | FBPase 2,D-fructose-1,6-bisphosphate 1-phosphohydrolase 2,Muscle FBPase |
| 2 | I, K, M, O, Q... (A, B, C, D, E...) | N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide | non-polymer | 474.4 | 8 | Chemie (96G) PubChem (24752356) | |||
| 3 | J, L, N, P, R... (A, B, C, D, E...) | 2,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 8 | Chemie (FDP) PubChem (483) PubChem (5460366) PubChem (9949812) PubChem (45109803) PubChem (50990584) PubChem (105021) PubChem (15764443) PubChem (124519606) PubChem (124519607) PubChem (124931522) PubChem (137794960) PubChem (162979383) | |||
| 4 | AA, BA, CA, DA, EA... (C, D, E, F, G...) | water | water | 18.0 | 545 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 1 - 339 (UniProt: O00757)
| PDB | External Database | Details |
|---|---|---|
| Leu 86 | Val 86 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 294384.8 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 6515.9 | |
| All* | Total formula weight | 300900.7 |
