5Q0C

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(4-methoxyphenyl)thiophen-2-yl]sulfonylurea and with fructose-2,6-diphosphate

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Functional Information from GO Data

ChainGOidnamespacecontents
A0030054cellular_componentcell junction
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0070062cellular_componentextracellular exosome
A0005654cellular_componentnucleoplasm
A0005886cellular_componentplasma membrane
A0030018cellular_componentZ disc
A0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
A0030388biological_processfructose 1,6-bisphosphate metabolic process
A0006002biological_processfructose 6-phosphate metabolic process
A0006000biological_processfructose metabolic process
A0006094biological_processgluconeogenesis
A0005986biological_processsucrose biosynthetic process
B0030054cellular_componentcell junction
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0070062cellular_componentextracellular exosome
B0005654cellular_componentnucleoplasm
B0005886cellular_componentplasma membrane
B0030018cellular_componentZ disc
B0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
B0042802molecular_functionidentical protein binding
B0046872molecular_functionmetal ion binding
B0030388biological_processfructose 1,6-bisphosphate metabolic process
B0006002biological_processfructose 6-phosphate metabolic process
B0006000biological_processfructose metabolic process
B0006094biological_processgluconeogenesis
B0005986biological_processsucrose biosynthetic process
C0030054cellular_componentcell junction
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0070062cellular_componentextracellular exosome
C0005654cellular_componentnucleoplasm
C0005886cellular_componentplasma membrane
C0030018cellular_componentZ disc
C0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
C0042802molecular_functionidentical protein binding
C0046872molecular_functionmetal ion binding
C0030388biological_processfructose 1,6-bisphosphate metabolic process
C0006002biological_processfructose 6-phosphate metabolic process
C0006000biological_processfructose metabolic process
C0006094biological_processgluconeogenesis
C0005986biological_processsucrose biosynthetic process
D0030054cellular_componentcell junction
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0070062cellular_componentextracellular exosome
D0005654cellular_componentnucleoplasm
D0005886cellular_componentplasma membrane
D0030018cellular_componentZ disc
D0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
D0042802molecular_functionidentical protein binding
D0046872molecular_functionmetal ion binding
D0030388biological_processfructose 1,6-bisphosphate metabolic process
D0006002biological_processfructose 6-phosphate metabolic process
D0006000biological_processfructose metabolic process
D0006094biological_processgluconeogenesis
D0005986biological_processsucrose biosynthetic process
E0030054cellular_componentcell junction
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0070062cellular_componentextracellular exosome
E0005654cellular_componentnucleoplasm
E0005886cellular_componentplasma membrane
E0030018cellular_componentZ disc
E0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
E0042802molecular_functionidentical protein binding
E0046872molecular_functionmetal ion binding
E0030388biological_processfructose 1,6-bisphosphate metabolic process
E0006002biological_processfructose 6-phosphate metabolic process
E0006000biological_processfructose metabolic process
E0006094biological_processgluconeogenesis
E0005986biological_processsucrose biosynthetic process
F0030054cellular_componentcell junction
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0070062cellular_componentextracellular exosome
F0005654cellular_componentnucleoplasm
F0005886cellular_componentplasma membrane
F0030018cellular_componentZ disc
F0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
F0042802molecular_functionidentical protein binding
F0046872molecular_functionmetal ion binding
F0030388biological_processfructose 1,6-bisphosphate metabolic process
F0006002biological_processfructose 6-phosphate metabolic process
F0006000biological_processfructose metabolic process
F0006094biological_processgluconeogenesis
F0005986biological_processsucrose biosynthetic process
G0030054cellular_componentcell junction
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0070062cellular_componentextracellular exosome
G0005654cellular_componentnucleoplasm
G0005886cellular_componentplasma membrane
G0030018cellular_componentZ disc
G0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
G0042802molecular_functionidentical protein binding
G0046872molecular_functionmetal ion binding
G0030388biological_processfructose 1,6-bisphosphate metabolic process
G0006002biological_processfructose 6-phosphate metabolic process
G0006000biological_processfructose metabolic process
G0006094biological_processgluconeogenesis
G0005986biological_processsucrose biosynthetic process
H0030054cellular_componentcell junction
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0070062cellular_componentextracellular exosome
H0005654cellular_componentnucleoplasm
H0005886cellular_componentplasma membrane
H0030018cellular_componentZ disc
H0042132molecular_functionfructose 1,6-bisphosphate 1-phosphatase activity
H0042802molecular_functionidentical protein binding
H0046872molecular_functionmetal ion binding
H0030388biological_processfructose 1,6-bisphosphate metabolic process
H0006002biological_processfructose 6-phosphate metabolic process
H0006000biological_processfructose metabolic process
H0006094biological_processgluconeogenesis
H0005986biological_processsucrose biosynthetic process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC115binding site for residue 96G A 401
ChainResidue
ALYS21
AGLY22
AARG23
AALA25
AGLY27
ATHR28
AGLY29
AGLU30
ALEU31
ATHR32
ATHR178
AGLN180
CTHR28
CGLY29
C96G401

AC218binding site for residue FDP A 402
ChainResidue
AASP122
AGLY123
ASER124
ASER125
AASN213
ATYR216
ATYR245
AGLY247
ASER248
AMET249
ATYR265
ALYS275
AGLU281
AHOH519
AHOH520
AHOH521
AHOH560
BARG244

AC316binding site for residue 96G B 401
ChainResidue
BMET19
BLYS21
BGLY22
BARG23
BALA25
BGLY27
BTHR28
BGLY29
BGLU30
BLEU31
BTHR32
BTHR178
BGLN180
BHOH521
DGLY29
D96G401

AC417binding site for residue FDP B 402
ChainResidue
AARG244
BASP122
BGLY123
BSER124
BSER125
BASN213
BTYR216
BTYR245
BGLY247
BSER248
BMET249
BTYR265
BLYS275
BGLU281
BHOH508
BHOH510
BHOH544

AC514binding site for residue 96G C 401
ChainResidue
A96G401
CLYS21
CGLY22
CARG23
CALA25
CGLY27
CTHR28
CGLY29
CGLU30
CLEU31
CTHR32
CTHR178
CGLN180
CHOH509

AC615binding site for residue FDP C 402
ChainResidue
CASP122
CGLY123
CSER124
CSER125
CASN213
CTYR216
CTYR245
CGLY247
CSER248
CMET249
CTYR265
CLYS275
CGLU281
CHOH519
DARG244

AC715binding site for residue 96G D 401
ChainResidue
BGLY29
B96G401
DLYS21
DGLY22
DARG23
DALA25
DGLY27
DTHR28
DGLY29
DGLU30
DLEU31
DTHR32
DTHR178
DGLN180
DHOH523

AC817binding site for residue FDP D 402
ChainResidue
CARG244
DASP122
DGLY123
DSER124
DSER125
DASN213
DTYR216
DTYR245
DGLY247
DSER248
DMET249
DTYR265
DLYS275
DGLU281
DHOH501
DHOH513
DHOH522

AC913binding site for residue 96G E 401
ChainResidue
EMET19
ELYS21
EGLY22
EARG23
EALA25
EGLY27
EGLY29
EGLU30
ELEU31
ETHR32
ETHR178
EGLN180
G96G401

AD116binding site for residue FDP E 402
ChainResidue
EASP122
EGLY123
ESER124
ESER125
EASN213
ETYR216
ETYR245
EGLY247
ESER248
EMET249
ETYR265
ELYS275
EGLU281
EHOH505
EHOH511
FARG244

AD215binding site for residue 96G F 401
ChainResidue
FMET19
FLYS21
FGLY22
FARG23
FALA25
FGLY27
FTHR28
FGLY29
FGLU30
FLEU31
FTHR32
FTHR178
FGLN180
FHOH524
H96G401

AD316binding site for residue FDP F 402
ChainResidue
EARG244
FASP122
FGLY123
FSER124
FSER125
FASN213
FTYR216
FTYR245
FGLY247
FSER248
FMET249
FTYR265
FLYS275
FGLU281
FHOH505
FHOH560

AD411binding site for residue 96G G 401
ChainResidue
E96G401
GLYS21
GGLY22
GARG23
GALA25
GGLY27
GGLY29
GGLU30
GLEU31
GTHR32
GGLN180

AD518binding site for residue FDP G 402
ChainResidue
GASP122
GGLY123
GSER124
GSER125
GASN213
GTYR216
GTYR245
GGLY247
GSER248
GMET249
GTYR265
GLYS275
GGLU281
GHOH507
GHOH518
GHOH527
GHOH540
HARG244

AD613binding site for residue 96G H 401
ChainResidue
F96G401
HMET19
HGLY22
HARG23
HALA25
HGLY27
HGLY29
HGLU30
HLEU31
HTHR32
HTHR178
HGLN180
HHOH526

AD716binding site for residue FDP H 402
ChainResidue
GARG244
HASP122
HGLY123
HSER124
HSER125
HASN213
HTYR216
HTYR245
HGLY247
HSER248
HMET249
HTYR265
HLYS275
HGLU281
HHOH511
HHOH535

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
96G_5q0c_A_40120N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site
ChainResidueligand
AVAL18-MET1996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
ALYS21-ARG2396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
AALA25-THR3296G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
ATYR11496G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
ATHR17896G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
AGLN18096G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
CTHR28-GLY2996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
CTHR32-GLN3396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide

96G_5q0c_C_40122N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site
ChainResidueligand
AGLY27-GLY2996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
ATHR32-GLN3396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
CVAL18-MET1996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
CLYS21-THR3296G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
CTYR11496G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
CTHR17896G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
CGLN18096G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide

FDP_5q0c_A_40219FRUCTOSE-2,6-DIPHOSPHATE binding site
ChainResidueligand
AASP119FDP: FRUCTOSE-2,6-DIPHOSPHATE
AASP122-ASN126FDP: FRUCTOSE-2,6-DIPHOSPHATE
AASN213FDP: FRUCTOSE-2,6-DIPHOSPHATE
ATYR216FDP: FRUCTOSE-2,6-DIPHOSPHATE
ATYR245FDP: FRUCTOSE-2,6-DIPHOSPHATE
AGLY247-VAL250FDP: FRUCTOSE-2,6-DIPHOSPHATE
APHE263FDP: FRUCTOSE-2,6-DIPHOSPHATE
ATYR265FDP: FRUCTOSE-2,6-DIPHOSPHATE
ALYS275-LEU276FDP: FRUCTOSE-2,6-DIPHOSPHATE
AGLU281FDP: FRUCTOSE-2,6-DIPHOSPHATE
BARG244FDP: FRUCTOSE-2,6-DIPHOSPHATE

FDP_5q0c_B_40219FRUCTOSE-2,6-DIPHOSPHATE binding site
ChainResidueligand
AARG244FDP: FRUCTOSE-2,6-DIPHOSPHATE
BASP119FDP: FRUCTOSE-2,6-DIPHOSPHATE
BASP122-ASN126FDP: FRUCTOSE-2,6-DIPHOSPHATE
BASN213FDP: FRUCTOSE-2,6-DIPHOSPHATE
BTYR216FDP: FRUCTOSE-2,6-DIPHOSPHATE
BTYR245FDP: FRUCTOSE-2,6-DIPHOSPHATE
BGLY247-VAL250FDP: FRUCTOSE-2,6-DIPHOSPHATE
BPHE263FDP: FRUCTOSE-2,6-DIPHOSPHATE
BTYR265FDP: FRUCTOSE-2,6-DIPHOSPHATE
BLYS275-LEU276FDP: FRUCTOSE-2,6-DIPHOSPHATE
BGLU281FDP: FRUCTOSE-2,6-DIPHOSPHATE

96G_5q0c_B_40121N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site
ChainResidueligand
BVAL18-MET1996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
BLYS21-THR3296G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
BTYR11496G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
BTHR17896G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
BGLN18096G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
DTHR28-GLY2996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
DTHR32-GLN3396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide

96G_5q0c_D_40119N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site
ChainResidueligand
BTHR28-GLY2996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
BTHR32-GLN3396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
DVAL18-MET1996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
DLYS21-ARG2396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
DALA2596G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
DGLY27-THR3296G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
DTYR11496G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
DTHR17896G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
DGLN18096G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide

FDP_5q0c_C_40219FRUCTOSE-2,6-DIPHOSPHATE binding site
ChainResidueligand
CASP119FDP: FRUCTOSE-2,6-DIPHOSPHATE
CASP122-ASN126FDP: FRUCTOSE-2,6-DIPHOSPHATE
CASN213FDP: FRUCTOSE-2,6-DIPHOSPHATE
CTYR216FDP: FRUCTOSE-2,6-DIPHOSPHATE
CTYR245FDP: FRUCTOSE-2,6-DIPHOSPHATE
CGLY247-VAL250FDP: FRUCTOSE-2,6-DIPHOSPHATE
CPHE263FDP: FRUCTOSE-2,6-DIPHOSPHATE
CTYR265FDP: FRUCTOSE-2,6-DIPHOSPHATE
CLYS275-LEU276FDP: FRUCTOSE-2,6-DIPHOSPHATE
CGLU281FDP: FRUCTOSE-2,6-DIPHOSPHATE
DARG244FDP: FRUCTOSE-2,6-DIPHOSPHATE

FDP_5q0c_D_40218FRUCTOSE-2,6-DIPHOSPHATE binding site
ChainResidueligand
CARG244FDP: FRUCTOSE-2,6-DIPHOSPHATE
DASP119FDP: FRUCTOSE-2,6-DIPHOSPHATE
DASP122-ASN126FDP: FRUCTOSE-2,6-DIPHOSPHATE
DASN213FDP: FRUCTOSE-2,6-DIPHOSPHATE
DTYR216FDP: FRUCTOSE-2,6-DIPHOSPHATE
DTYR245FDP: FRUCTOSE-2,6-DIPHOSPHATE
DGLY247-MET249FDP: FRUCTOSE-2,6-DIPHOSPHATE
DPHE263FDP: FRUCTOSE-2,6-DIPHOSPHATE
DTYR265FDP: FRUCTOSE-2,6-DIPHOSPHATE
DLYS275-LEU276FDP: FRUCTOSE-2,6-DIPHOSPHATE
DGLU281FDP: FRUCTOSE-2,6-DIPHOSPHATE

96G_5q0c_E_40121N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site
ChainResidueligand
EVAL18-MET1996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
ELYS21-THR3296G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
ETYR11496G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
ETHR17896G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
EGLN18096G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
GTHR28-GLY2996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
GTHR32-GLN3396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide

96G_5q0c_G_40121N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site
ChainResidueligand
ETHR28-GLY2996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
ETHR32-GLN3396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
GVAL18-MET1996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
GLYS21-ARG2396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
GALA25-GLN3396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
GTYR11496G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
GTHR17896G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
GGLN18096G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide

FDP_5q0c_E_40219FRUCTOSE-2,6-DIPHOSPHATE binding site
ChainResidueligand
EASP119FDP: FRUCTOSE-2,6-DIPHOSPHATE
EASP122-ASN126FDP: FRUCTOSE-2,6-DIPHOSPHATE
EASN213FDP: FRUCTOSE-2,6-DIPHOSPHATE
ETYR216FDP: FRUCTOSE-2,6-DIPHOSPHATE
ETYR245FDP: FRUCTOSE-2,6-DIPHOSPHATE
EGLY247-VAL250FDP: FRUCTOSE-2,6-DIPHOSPHATE
EPHE263FDP: FRUCTOSE-2,6-DIPHOSPHATE
ETYR265FDP: FRUCTOSE-2,6-DIPHOSPHATE
ELYS275-LEU276FDP: FRUCTOSE-2,6-DIPHOSPHATE
EGLU281FDP: FRUCTOSE-2,6-DIPHOSPHATE
FARG244FDP: FRUCTOSE-2,6-DIPHOSPHATE

FDP_5q0c_F_40219FRUCTOSE-2,6-DIPHOSPHATE binding site
ChainResidueligand
EARG244FDP: FRUCTOSE-2,6-DIPHOSPHATE
FASP119FDP: FRUCTOSE-2,6-DIPHOSPHATE
FASP122-ASN126FDP: FRUCTOSE-2,6-DIPHOSPHATE
FASN213FDP: FRUCTOSE-2,6-DIPHOSPHATE
FTYR216FDP: FRUCTOSE-2,6-DIPHOSPHATE
FTYR245FDP: FRUCTOSE-2,6-DIPHOSPHATE
FGLY247-MET249FDP: FRUCTOSE-2,6-DIPHOSPHATE
FASP252FDP: FRUCTOSE-2,6-DIPHOSPHATE
FPHE263FDP: FRUCTOSE-2,6-DIPHOSPHATE
FTYR265FDP: FRUCTOSE-2,6-DIPHOSPHATE
FLYS275-LEU276FDP: FRUCTOSE-2,6-DIPHOSPHATE
FGLU281FDP: FRUCTOSE-2,6-DIPHOSPHATE

96G_5q0c_F_40120N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site
ChainResidueligand
FVAL18-MET1996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
FLYS21-ARG2396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
FALA25-THR3296G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
FTYR11496G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
FTHR17896G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
FGLN18096G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
HTHR28-GLY2996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
HTHR32-GLN3396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide

96G_5q0c_H_40121N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide binding site
ChainResidueligand
FTHR28-GLY2996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
FTHR32-GLN3396G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
HVAL18-MET1996G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
HLYS21-THR3296G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
HTYR11496G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
HTHR17896G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide
HGLN18096G: N-[(5-bromo-1,3-thiazol-2-yl)carbamoyl]-5-(4-methoxyphenyl)thiophene-2-sulfonamide

FDP_5q0c_G_40218FRUCTOSE-2,6-DIPHOSPHATE binding site
ChainResidueligand
GASP122-ASN126FDP: FRUCTOSE-2,6-DIPHOSPHATE
GASN213FDP: FRUCTOSE-2,6-DIPHOSPHATE
GTYR216FDP: FRUCTOSE-2,6-DIPHOSPHATE
GTYR245FDP: FRUCTOSE-2,6-DIPHOSPHATE
GGLY247-VAL250FDP: FRUCTOSE-2,6-DIPHOSPHATE
GPHE263FDP: FRUCTOSE-2,6-DIPHOSPHATE
GTYR265FDP: FRUCTOSE-2,6-DIPHOSPHATE
GLYS275-LEU276FDP: FRUCTOSE-2,6-DIPHOSPHATE
GGLU281FDP: FRUCTOSE-2,6-DIPHOSPHATE
HARG244FDP: FRUCTOSE-2,6-DIPHOSPHATE

FDP_5q0c_H_40218FRUCTOSE-2,6-DIPHOSPHATE binding site
ChainResidueligand
GARG244FDP: FRUCTOSE-2,6-DIPHOSPHATE
HASP119FDP: FRUCTOSE-2,6-DIPHOSPHATE
HASP122-ASN126FDP: FRUCTOSE-2,6-DIPHOSPHATE
HASN213FDP: FRUCTOSE-2,6-DIPHOSPHATE
HTYR216FDP: FRUCTOSE-2,6-DIPHOSPHATE
HTYR245FDP: FRUCTOSE-2,6-DIPHOSPHATE
HGLY247-MET249FDP: FRUCTOSE-2,6-DIPHOSPHATE
HPHE263FDP: FRUCTOSE-2,6-DIPHOSPHATE
HTYR265FDP: FRUCTOSE-2,6-DIPHOSPHATE
HLYS275-LEU276FDP: FRUCTOSE-2,6-DIPHOSPHATE
HGLU281FDP: FRUCTOSE-2,6-DIPHOSPHATE

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Functional Information from PROSITE/UniProt

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Functional Information from SwissProt/UniProt

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Catalytic Information from CSA

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