5Q0C

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[5-(4-methoxyphenyl)thiophen-2-yl]sulfonylurea and with fructose-2,6-diphosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005975	biological_process	carbohydrate metabolic process
A	0006000	biological_process	fructose metabolic process
A	0006002	biological_process	fructose 6-phosphate metabolic process
A	0006094	biological_process	gluconeogenesis
A	0016787	molecular_function	hydrolase activity
A	0016791	molecular_function	phosphatase activity
A	0030018	cellular_component	Z disc
A	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
A	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
A	0042578	molecular_function	phosphoric ester hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0070161	cellular_component	anchoring junction
B	0003824	molecular_function	catalytic activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005975	biological_process	carbohydrate metabolic process
B	0006000	biological_process	fructose metabolic process
B	0006002	biological_process	fructose 6-phosphate metabolic process
B	0006094	biological_process	gluconeogenesis
B	0016787	molecular_function	hydrolase activity
B	0016791	molecular_function	phosphatase activity
B	0030018	cellular_component	Z disc
B	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
B	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
B	0042578	molecular_function	phosphoric ester hydrolase activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0070161	cellular_component	anchoring junction
C	0003824	molecular_function	catalytic activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0005975	biological_process	carbohydrate metabolic process
C	0006000	biological_process	fructose metabolic process
C	0006002	biological_process	fructose 6-phosphate metabolic process
C	0006094	biological_process	gluconeogenesis
C	0016787	molecular_function	hydrolase activity
C	0016791	molecular_function	phosphatase activity
C	0030018	cellular_component	Z disc
C	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
C	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
C	0042578	molecular_function	phosphoric ester hydrolase activity
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0070161	cellular_component	anchoring junction
D	0003824	molecular_function	catalytic activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005975	biological_process	carbohydrate metabolic process
D	0006000	biological_process	fructose metabolic process
D	0006002	biological_process	fructose 6-phosphate metabolic process
D	0006094	biological_process	gluconeogenesis
D	0016787	molecular_function	hydrolase activity
D	0016791	molecular_function	phosphatase activity
D	0030018	cellular_component	Z disc
D	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
D	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
D	0042578	molecular_function	phosphoric ester hydrolase activity
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0070161	cellular_component	anchoring junction
E	0003824	molecular_function	catalytic activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0005975	biological_process	carbohydrate metabolic process
E	0006000	biological_process	fructose metabolic process
E	0006002	biological_process	fructose 6-phosphate metabolic process
E	0006094	biological_process	gluconeogenesis
E	0016787	molecular_function	hydrolase activity
E	0016791	molecular_function	phosphatase activity
E	0030018	cellular_component	Z disc
E	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
E	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
E	0042578	molecular_function	phosphoric ester hydrolase activity
E	0042802	molecular_function	identical protein binding
E	0046872	molecular_function	metal ion binding
E	0070062	cellular_component	extracellular exosome
E	0070161	cellular_component	anchoring junction
F	0003824	molecular_function	catalytic activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005886	cellular_component	plasma membrane
F	0005975	biological_process	carbohydrate metabolic process
F	0006000	biological_process	fructose metabolic process
F	0006002	biological_process	fructose 6-phosphate metabolic process
F	0006094	biological_process	gluconeogenesis
F	0016787	molecular_function	hydrolase activity
F	0016791	molecular_function	phosphatase activity
F	0030018	cellular_component	Z disc
F	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
F	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
F	0042578	molecular_function	phosphoric ester hydrolase activity
F	0042802	molecular_function	identical protein binding
F	0046872	molecular_function	metal ion binding
F	0070062	cellular_component	extracellular exosome
F	0070161	cellular_component	anchoring junction
G	0003824	molecular_function	catalytic activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005975	biological_process	carbohydrate metabolic process
G	0006000	biological_process	fructose metabolic process
G	0006002	biological_process	fructose 6-phosphate metabolic process
G	0006094	biological_process	gluconeogenesis
G	0016787	molecular_function	hydrolase activity
G	0016791	molecular_function	phosphatase activity
G	0030018	cellular_component	Z disc
G	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
G	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
G	0042578	molecular_function	phosphoric ester hydrolase activity
G	0042802	molecular_function	identical protein binding
G	0046872	molecular_function	metal ion binding
G	0070062	cellular_component	extracellular exosome
G	0070161	cellular_component	anchoring junction
H	0003824	molecular_function	catalytic activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0005975	biological_process	carbohydrate metabolic process
H	0006000	biological_process	fructose metabolic process
H	0006002	biological_process	fructose 6-phosphate metabolic process
H	0006094	biological_process	gluconeogenesis
H	0016787	molecular_function	hydrolase activity
H	0016791	molecular_function	phosphatase activity
H	0030018	cellular_component	Z disc
H	0030388	biological_process	fructose 1,6-bisphosphate metabolic process
H	0042132	molecular_function	fructose 1,6-bisphosphate 1-phosphatase activity
H	0042578	molecular_function	phosphoric ester hydrolase activity
H	0042802	molecular_function	identical protein binding
H	0046872	molecular_function	metal ion binding
H	0070062	cellular_component	extracellular exosome
H	0070161	cellular_component	anchoring junction

Functional Information from PROSITE/UniProt

site_id	PS00124
Number of Residues	13
Details	FBPASE Fructose-1-6-bisphosphatase active site. GKLrlLYEcnPVA

Chain	Residue	Details
A	GLY274-ALA286

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"19626708","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22120740","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	119
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Site: {"description":"Important for the conversion from active R-state to inactive T-state in the presence of AMP"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9Z1N1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---