5OJO
Sirtuin 5 from Danio rerio in complex with 3-hydroxy-3-methylglutaryl-CPS1 peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NAD-dependent protein deacylase sirtuin-5, mitochondrial | polymer | 275 | 30423.8 | 2 | UniProt (Q6DHI5) Pfam (PF02146) | Danio rerio (Zebrafish) | Regulatory protein SIR2 homolog 5 |
| 2 | C (C) | Carbamoyl-phosphate synthase [ammonia], mitochondrial | polymer | 8 | 1112.2 | 1 | UniProt (P31327) | Homo sapiens | Carbamoyl-phosphate synthetase I,CPSase I |
| 3 | D (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 4 | E, H (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 5 | F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 6 | G (B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 1 | Chemie (EPE) | |||
| 7 | I (B) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | J, K, L (A, B, C) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
A, B: 30 - 298 (UniProt: Q6DHI5)
C: 1 - 8 (UniProt: P31327)
| PDB | External Database | Details |
|---|---|---|
| Gly 24 | - | expression tag |
| Ile 25 | - | expression tag |
| Asp 26 | - | expression tag |
| Pro 27 | - | expression tag |
| Phe 28 | - | expression tag |
| Thr 29 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Hly 4 | Lys 527 | microheterogeneity |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 61959.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 532.3 | |
| All* | Total formula weight | 62492.1 |
