5OJO

Sirtuin 5 from Danio rerio in complex with 3-hydroxy-3-methylglutaryl-CPS1 peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	NAD-dependent protein deacylase sirtuin-5, mitochondrial	polymer	275	30423.8	2	UniProt (Q6DHI5) Pfam (PF02146) In PDB	Danio rerio (Zebrafish)	Regulatory protein SIR2 homolog 5
2	C	Carbamoyl-phosphate synthase [ammonia], mitochondrial	polymer	8	1112.2	1	UniProt (P31327) In PDB	Homo sapiens	Carbamoyl-phosphate synthetase I,CPSase I
3	A	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
4	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
5	A	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6	B	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID	non-polymer		238.3	1	Chemie (EPE)
7	B	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
8		water	water		18.0	59	Chemie (HOH)

Sequence modifications

A, B: 30 - 298 (UniProt: Q6DHI5)

PDB	External Database	Details
Gly 24	-	expression tag
Ile 25	-	expression tag
Asp 26	-	expression tag
Pro 27	-	expression tag
Phe 28	-	expression tag
Thr 29	-	expression tag

C: 1 - 8 (UniProt: P31327)

PDB	External Database	Details
Hly 4	Lys 527	microheterogeneity

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	61959.8
Non-Polymers*	Number of molecules	6
	Total formula weight	532.3
All*	Total formula weight	62492.1

*Water molecules are not included.