5OF4
The cryo-EM structure of human TFIIH
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TFIIH basal transcription factor complex helicase XPB subunit,XPB,TFIIH basal transcription factor complex helicase XPB subunit | polymer | 553 | 62426.0 | 1 | UniProt (P19447) Pfam (PF04851) Pfam (PF16203) | Homo sapiens (Human) | Basic transcription factor 2 89 kDa subunit,BTF2 p89,DNA excision repair protein ERCC-3,DNA repair protein complementing XP-B cells,TFIIH basal transcription factor complex 89 kDa subunit,TFIIH p89,Xeroderma pigmentosum group B-complementing protein,Basic transcription factor 2 89 kDa subunit,BTF2 p89,DNA excision repair protein ERCC-3,DNA repair protein complementing XP-B cells,TFIIH basal transcription factor complex 89 kDa subunit,TFIIH p89,Xeroderma pigmentosum group B-complementing protein |
| 2 | B (B) | TFIIH basal transcription factor complex helicase XPD subunit | polymer | 760 | 87021.1 | 1 | UniProt (P18074) Pfam (PF06733) Pfam (PF06777) Pfam (PF13307) | Homo sapiens (Human) | Basic transcription factor 2 80 kDa subunit,BTF2 p80,CXPD,DNA excision repair protein ERCC-2,DNA repair protein complementing XP-D cells,TFIIH basal transcription factor complex 80 kDa subunit,TFIIH p80,Xeroderma pigmentosum group D-complementing protein |
| 3 | C (D) | General transcription factor IIH subunit 4,p52,General transcription factor IIH subunit 4 | polymer | 85 | 9875.4 | 1 | UniProt (Q92759) Pfam (PF18307) | Homo sapiens (Human) | Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,TFIIH basal transcription factor complex p52 subunit,Basic transcription factor 2 52 kDa subunit,BTF2 p52,General transcription factor IIH polypeptide 4,TFIIH basal transcription factor complex p52 subunit |
| 4 | D (E) | General transcription factor IIH subunit 2 | polymer | 395 | 44482.0 | 1 | UniProt (Q13888) Pfam (PF04056) Pfam (PF07975) | Homo sapiens (Human) | Basic transcription factor 2 44 kDa subunit,BTF2 p44,General transcription factor IIH polypeptide 2,TFIIH basal transcription factor complex p44 subunit |
| 5 | E (F) | General transcription factor IIH subunit 3 | polymer | 308 | 34416.0 | 1 | UniProt (Q13889) Pfam (PF03850) | Homo sapiens (Human) | Basic transcription factor 2 34 kDa subunit,BTF2 p34,General transcription factor IIH polypeptide 3,TFIIH basal transcription factor complex p34 subunit |
| 6 | F (G) | General transcription factor IIH subunit 5 | polymer | 71 | 8060.4 | 1 | UniProt (Q6ZYL4) Pfam (PF06331) | Homo sapiens (Human) | General transcription factor IIH polypeptide 5,TFB5 ortholog,TFIIH basal transcription factor complex TTD-A subunit |
| 7 | G (H) | MAT1 | polymer | 124 | 10571.0 | 1 | Homo sapiens | ||
| 8 | H (Z) | Unassigned secondary structure elements. | polymer | 270 | 22996.2 | 1 | Homo sapiens | ||
| 9 | I (Y) | Unassigned secondary structure elements (p52 region) | polymer | 232 | 19762.3 | 1 | Homo sapiens | ||
| 10 | J (X) | Unassigned secondary structure elements (XPB NTE region) | polymer | 78 | 6656.2 | 1 | Homo sapiens | ||
| 11 | K (B) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 1 | Chemie (SF4) |
Sequence modifications
A: 221 - 256 (PDB: 5OF4)
A: 266 - 782 (UniProt: P19447)
D: 378 - 383 (PDB: 5OF4)
D: 384 - 462 (UniProt: Q92759)
A: 266 - 782 (UniProt: P19447)
D: 378 - 383 (PDB: 5OF4)
D: 384 - 462 (UniProt: Q92759)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 306266.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 351.6 | |
| All* | Total formula weight | 306618.3 |
