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5OF4

The cryo-EM structure of human TFIIH

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003678molecular_functionDNA helicase activity
A0005524molecular_functionATP binding
A0006289biological_processnucleotide-excision repair
A0006367biological_processtranscription initiation at RNA polymerase II promoter
A0016787molecular_functionhydrolase activity
B0000439cellular_componenttranscription factor TFIIH core complex
B0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B0001666biological_processresponse to hypoxia
B0001701biological_processin utero embryonic development
B0003676molecular_functionnucleic acid binding
B0003677molecular_functionDNA binding
B0003678molecular_functionDNA helicase activity
B0003684molecular_functiondamaged DNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005669cellular_componenttranscription factor TFIID complex
B0005675cellular_componenttranscription factor TFIIH holo complex
B0005737cellular_componentcytoplasm
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0006139biological_processnucleobase-containing compound metabolic process
B0006259biological_processDNA metabolic process
B0006281biological_processDNA repair
B0006283biological_processtranscription-coupled nucleotide-excision repair
B0006289biological_processnucleotide-excision repair
B0006357biological_processregulation of transcription by RNA polymerase II
B0006362biological_processtranscription elongation by RNA polymerase I
B0006366biological_processtranscription by RNA polymerase II
B0006367biological_processtranscription initiation at RNA polymerase II promoter
B0006915biological_processapoptotic process
B0006974biological_processDNA damage response
B0006979biological_processresponse to oxidative stress
B0007059biological_processchromosome segregation
B0008340biological_processdetermination of adult lifespan
B0009411biological_processresponse to UV
B0009650biological_processUV protection
B0009791biological_processpost-embryonic development
B0016787molecular_functionhydrolase activity
B0016818molecular_functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B0016853molecular_functionisomerase activity
B0016887molecular_functionATP hydrolysis activity
B0021510biological_processspinal cord development
B0022405biological_processhair cycle process
B0030198biological_processextracellular matrix organization
B0030282biological_processbone mineralization
B0030674molecular_functionprotein-macromolecule adaptor activity
B0032289biological_processcentral nervous system myelin formation
B0032508biological_processDNA duplex unwinding
B0035264biological_processmulticellular organism growth
B0035315biological_processhair cell differentiation
B0040016biological_processembryonic cleavage
B0042274biological_processribosomal small subunit biogenesis
B0043139molecular_function5'-3' DNA helicase activity
B0043249biological_processerythrocyte maturation
B0043588biological_processskin development
B0045951biological_processpositive regulation of mitotic recombination
B0046872molecular_functionmetal ion binding
B0048009biological_processinsulin-like growth factor receptor signaling pathway
B0048568biological_processembryonic organ development
B0048820biological_processhair follicle maturation
B0051539molecular_function4 iron, 4 sulfur cluster binding
B0060218biological_processhematopoietic stem cell differentiation
B0070516cellular_componentCAK-ERCC2 complex
B0071425biological_processhematopoietic stem cell proliferation
B0071817cellular_componentMMXD complex
B0072332biological_processintrinsic apoptotic signaling pathway by p53 class mediator
B1901990biological_processregulation of mitotic cell cycle phase transition
D0000439cellular_componenttranscription factor TFIIH core complex
D0001671molecular_functionATPase activator activity
D0006289biological_processnucleotide-excision repair
E0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
E0000439cellular_componenttranscription factor TFIIH core complex
E0002031biological_processG protein-coupled receptor internalization
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005669cellular_componenttranscription factor TFIID complex
E0005675cellular_componenttranscription factor TFIIH holo complex
E0006281biological_processDNA repair
E0006289biological_processnucleotide-excision repair
E0006351biological_processDNA-templated transcription
E0006357biological_processregulation of transcription by RNA polymerase II
E0006366biological_processtranscription by RNA polymerase II
E0006367biological_processtranscription initiation at RNA polymerase II promoter
E0008270molecular_functionzinc ion binding
E0009411biological_processresponse to UV
E0016251molecular_functionRNA polymerase II general transcription initiation factor activity
E0016607cellular_componentnuclear speck
E0046872molecular_functionmetal ion binding
F0000438cellular_componentcore TFIIH complex portion of holo TFIIH complex
F0000439cellular_componenttranscription factor TFIIH core complex
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005669cellular_componenttranscription factor TFIID complex
F0005675cellular_componenttranscription factor TFIIH holo complex
F0006281biological_processDNA repair
F0006289biological_processnucleotide-excision repair
F0006355biological_processregulation of DNA-templated transcription
F0006366biological_processtranscription by RNA polymerase II
F0016251molecular_functionRNA polymerase II general transcription initiation factor activity
F0046872molecular_functionmetal ion binding
F0097550cellular_componenttranscription preinitiation complex
G0000439cellular_componenttranscription factor TFIIH core complex
G0000462biological_processmaturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005669cellular_componenttranscription factor TFIID complex
G0005675cellular_componenttranscription factor TFIIH holo complex
G0005730cellular_componentnucleolus
G0005737cellular_componentcytoplasm
G0006281biological_processDNA repair
G0006289biological_processnucleotide-excision repair
G0006294biological_processnucleotide-excision repair, preincision complex assembly
G0006362biological_processtranscription elongation by RNA polymerase I
G0006366biological_processtranscription by RNA polymerase II
G0006367biological_processtranscription initiation at RNA polymerase II promoter
G0071480biological_processcellular response to gamma radiation
Functional Information from PDB Data
site_idAC1
Number of Residues8
Detailsbinding site for residue SF4 B 1000
ChainResidue
BLEU115
BCYS116
BHIS118
BCYS134
BCYS155
BPHE157
BCYS190
BPHE193

Functional Information from PROSITE/UniProt
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H
ChainResidueDetails
ECYS360-HIS380

site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN
ChainResidueDetails
BALA229-ASN238

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:17525332
ChainResidueDetails
GTHR69

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:A0JN27
ChainResidueDetails
ETYR95
BCYS134
BCYS155
BCYS190

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER686

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine; by CK2 => ECO:0000305|PubMed:15549133
ChainResidueDetails
ASER751

223790

PDB entries from 2024-08-14

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