5ODT
Aurora-A in complex with TACC3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aurora kinase A | polymer | 283 | 32755.5 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | B | Transforming acidic coiled-coil-containing protein 3 | polymer | 46 | 5281.9 | 1 | UniProt (Q9Y6A5) In PDB | Homo sapiens (Human) | ERIC-1 |
| 3 | A | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 5 | A, B | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 6 | water | water | 18.0 | 140 | Chemie (HOH) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
B: 519 - 563 (UniProt: Q9Y6A5)
| PDB | External Database | Details |
|---|---|---|
| Met 121 | - | initiating methionine |
| Asn 274 | Asp 274 | engineered mutation |
| Ala 290 | Cys 290 | engineered mutation |
| Ala 393 | Cys 393 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met 518 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 38037.4 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1087.7 | |
| All* | Total formula weight | 39125.2 |
