5ODT
Aurora-A in complex with TACC3
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | binding site for residue ADP A 501 |
| Chain | Residue |
| A | LEU139 |
| A | HIS280 |
| A | HOH601 |
| A | HOH627 |
| A | HOH644 |
| A | HOH656 |
| A | HOH669 |
| A | HOH675 |
| A | LYS162 |
| A | LEU194 |
| A | GLU211 |
| A | TYR212 |
| A | ALA213 |
| A | LEU263 |
| A | SER278 |
| A | VAL279 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 502 |
| Chain | Residue |
| A | SER245 |
| A | HIS248 |
| A | MET373 |
| A | LEU374 |
| A | ARG375 |
| A | HOH612 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | LYS156 |
| A | ILE158 |
| B | PHE544 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | HIS280 |
| A | SO4506 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | ARG195 |
| B | LYS550 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | GLY142 |
| A | LYS143 |
| A | VAL279 |
| A | HIS280 |
| A | GOL504 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | ARG304 |
| A | MET305 |
| A | HOH631 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 601 |
| Chain | Residue |
| A | ASN146 |
| A | TYR148 |
| A | ARG205 |
| A | HOH609 |
| B | GLY533 |
| B | THR534 |
| B | GLY535 |
| B | ALA536 |
| B | HOH706 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGKFGNVYlArekqskfi..........LALK |
| Chain | Residue | Details |
| A | LEU139-LYS162 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKpeNLLL |
| Chain | Residue | Details |
| A | VAL252-LEU264 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"14580337","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27837025","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G1X","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA and PAK","evidences":[{"source":"PubMed","id":"16246726","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by AURKA","evidences":[{"source":"PubMed","id":"17545617","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
