5O4A
Human FGF in complex with a covalent inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Fibroblast growth factor receptor 1 | polymer | 309 | 35135.3 | 2 | UniProt (P11362) Pfam (PF07714) In PDB | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 2 | A, B | SULFATE ION | non-polymer | 96.1 | 3 | Chemie (SO4) | |||
| 3 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | A, B | [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl 4-ethyl-3-fluorosulfonyl-benzoate | non-polymer | 481.5 | 2 | Chemie (9K8) | |||
| 5 | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A, B: 458 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 457 | - | expression tag |
| Ala 488 | Cys 488 | conflict |
| Ser 584 | Cys 584 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70270.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1343.2 | |
| All* | Total formula weight | 71613.9 |
