5O1O

Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with proline bound.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Alpha-aminoadipic semialdehyde synthase, mitochondrial	polymer	497	54608.8	2	UniProt (Q9UDR5) Pfam (PF03435) Pfam (PF16653)	Homo sapiens (Human)	LKR/SDH
2	C, E (A, B)	1,2-ETHANEDIOL	non-polymer		62.1	2	Chemie (EDO)
3	D, F (A, B)	PROLINE	non-polymer		115.1	2	Chemie (PRO)
4	G, H (A, B)	water	water		18.0	12	Chemie (HOH)

Sequence modifications

A, B: 455 - 926 (UniProt: Q9UDR5)

PDB	External Database	Details
Met 430	-	initiating methionine
Gly 431	-	expression tag
His 432	-	expression tag
His 433	-	expression tag
His 434	-	expression tag
His 435	-	expression tag
His 436	-	expression tag
His 437	-	expression tag
Ser 438	-	expression tag
Ser 439	-	expression tag
Gly 440	-	expression tag
Val 441	-	expression tag
Asp 442	-	expression tag
Leu 443	-	expression tag
Gly 444	-	expression tag
Thr 445	-	expression tag
Glu 446	-	expression tag
Asn 447	-	expression tag
Leu 448	-	expression tag
Tyr 449	-	expression tag
Phe 450	-	expression tag
Gln 451	-	expression tag
Ser 452	-	expression tag
Met 453	-	expression tag
Ala 454	-	expression tag
Ser 615	Thr 615	cloning artifact

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	109217.6
Non-Polymers*	Number of molecules	4
	Total formula weight	354.4
All*	Total formula weight	109572.0

*Water molecules are not included.