5O1N
Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Alpha-aminoadipic semialdehyde synthase, mitochondrial | polymer | 497 | 54608.8 | 1 | UniProt (Q9UDR5) Pfam (PF03435) Pfam (PF16653) In PDB | Homo sapiens (Human) | LKR/SDH |
2 | A | 1,1,1-tris(fluoranyl)-~{N}-[[(2~{S})-pyrrolidin-2-yl]methyl]methanesulfonamide | non-polymer | 232.2 | 1 | Chemie (9H8) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
4 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
5 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
6 | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A: 455 - 926 (UniProt: Q9UDR5)
PDB | External Database | Details |
---|---|---|
Met 430 | - | initiating methionine |
Gly 431 | - | expression tag |
His 432 | - | expression tag |
His 433 | - | expression tag |
His 434 | - | expression tag |
His 435 | - | expression tag |
His 436 | - | expression tag |
His 437 | - | expression tag |
Ser 438 | - | expression tag |
Ser 439 | - | expression tag |
Gly 440 | - | expression tag |
Val 441 | - | expression tag |
Asp 442 | - | expression tag |
Leu 443 | - | expression tag |
Gly 444 | - | expression tag |
Thr 445 | - | expression tag |
Glu 446 | - | expression tag |
Asn 447 | - | expression tag |
Leu 448 | - | expression tag |
Tyr 449 | - | expression tag |
Phe 450 | - | expression tag |
Gln 451 | - | expression tag |
Ser 452 | - | expression tag |
Met 453 | - | expression tag |
Ala 454 | - | expression tag |
Ser 615 | Thr 615 | conflict |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 54608.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 478.5 | |
All* | Total formula weight | 55087.4 |