5O1N
Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016491 | molecular_function | oxidoreductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | binding site for residue 9H8 A 1001 |
| Chain | Residue |
| A | ASP604 |
| A | DMS1002 |
| A | PEG1004 |
| A | HOH1107 |
| A | GLY634 |
| A | GLY635 |
| A | TYR648 |
| A | TRP652 |
| A | ASN702 |
| A | THR724 |
| A | ARG726 |
| A | MET870 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue DMS A 1002 |
| Chain | Residue |
| A | TYR648 |
| A | PHE650 |
| A | SER651 |
| A | TRP652 |
| A | SER653 |
| A | 9H81001 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 1003 |
| Chain | Residue |
| A | SER848 |
| A | HIS850 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 1004 |
| Chain | Residue |
| A | ALA576 |
| A | SER577 |
| A | LEU601 |
| A | ASP604 |
| A | 9H81001 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2016","submissionDatabase":"PDB data bank","title":"Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in NAD+ bound form).","authors":["Kopec J.","Yue W.W."]}},{"source":"PDB","id":"5L78","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9P4R4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q99K67","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q99K67","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99K67","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
