5O1N

Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 9H8 A 1001

Chain	Residue
A	ASP604
A	DMS1002
A	PEG1004
A	HOH1107
A	GLY634
A	GLY635
A	TYR648
A	TRP652
A	ASN702
A	THR724
A	ARG726
A	MET870

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site_id	AC2
Number of Residues	6
Details	binding site for residue DMS A 1002

Chain	Residue
A	TYR648
A	PHE650
A	SER651
A	TRP652
A	SER653
A	9H81001

---

site_id	AC3
Number of Residues	2
Details	binding site for residue EDO A 1003

Chain	Residue
A	SER848
A	HIS850

---

site_id	AC4
Number of Residues	5
Details	binding site for residue PEG A 1004

Chain	Residue
A	ALA576
A	SER577
A	LEU601
A	ASP604
A	9H81001

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	BINDING: BINDING => ECO:0000269|Ref.8, ECO:0007744|PDB:5L78

Chain	Residue	Details
A	SER488
A	PRO605
A	ASP512
A	GLN516
A	ILE533
A	LEU554
A	ALA576
A	SER577
A	LEU603
A	ASP604

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9P4R4

Chain	Residue	Details
A	ARG703
A	THR724

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q99K67

Chain	Residue	Details
A	LYS458
A	LYS523
A	LYS535
A	LYS584
A	LYS761

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q99K67

Chain	Residue	Details
A	LYS707
A	LYS739
A	LYS780

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q99K67

Chain	Residue	Details
A	LYS732

---