5NW4
Human cytoplasmic dynein-1 bound to dynactin and an N-terminal construct of BICD2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | dynein heavy chain | polymer | 889 | 75675.7 | 1 | Homo sapiens (Human) | ||
| 2 | B (D) | dynein intermediate chain | polymer | 341 | 29038.7 | 1 | Homo sapiens (Human) | ||
| 3 | C (C) | dynein intermediate chain | polymer | 350 | 29804.6 | 1 | Homo sapiens (Human) | ||
| 4 | D (A) | dynein heavy chain | polymer | 922 | 78484.1 | 1 | Homo sapiens (Human) | ||
| 5 | E (1) | dynein N-terminal dimerization domain | polymer | 125 | 10656.1 | 1 | Homo sapiens (Human) | ||
| 6 | F (2) | dynein N-terminal dimerization domain | polymer | 124 | 10571.0 | 1 | Homo sapiens (Human) | ||
| 7 | G, H (R, S) | Robl | polymer | 120 | 10230.6 | 2 | Homo sapiens (Human) | ||
| 8 | I (E) | dynein light intermediate chain | polymer | 295 | 25123.8 | 1 | Homo sapiens (Human) | ||
| 9 | J (F) | dynein light intermediate chain | polymer | 298 | 25379.1 | 1 | Homo sapiens (Human) | ||
| 10 | K, L, M, N, O... (G, H, O, P, Q...) | Arp1 | polymer | 376 | 42684.7 | 8 | UniProt (F2Z5G5) Pfam (PF00022) | Sus scrofa (Pig) | |
| 11 | R (V) | beta-actin | polymer | 396 | 43987.1 | 1 | UniProt (I3LVD5) Pfam (PF00022) UniProt (by SIFTS) (A0A151MAL5) | Sus scrofa (Pig) | |
| 12 | T (X) | Arp11 | polymer | 417 | 46250.8 | 1 | UniProt (I3LHK5) Pfam (PF00022) | Sus scrofa (Pig) | |
| 13 | U (Y) | Capping protein (Actin filament) muscle Z-line, alpha 1 | polymer | 286 | 33059.8 | 1 | UniProt (A0PFK5) Pfam (PF01267) | Sus scrofa (Pig) | F-actin capping protein alpha 1 subunit,F-actin capping protein subunit alpha 1 |
| 14 | V (Z) | F-actin capping protein beta subunit variant II | polymer | 293 | 33060.4 | 1 | UniProt (D2JYW4) Pfam (PF01115) | Sus scrofa (Pig) | F-actin-capping protein subunit beta,F-actin-capping protein subunit beta isoform 2 |
| 15 | W (a) | dynactin shoulder complex | polymer | 571 | 48613.0 | 1 | Sus scrofa (Pig) | ||
| 16 | X (b) | dynactin shoulder complex | polymer | 602 | 51251.3 | 1 | Sus scrofa (Pig) | ||
| 17 | Y, Z (c, d) | dynactin shoulder complex | polymer | 130 | 11081.7 | 2 | Sus scrofa (Pig) | ||
| 18 | AA, BA (e, f) | dynactin shoulder complex | polymer | 174 | 14826.3 | 2 | Sus scrofa (Pig) | ||
| 19 | CA (g) | Dynactin 6 | polymer | 190 | 20703.9 | 1 | UniProt (D0G6S1) | Sus scrofa (Pig) | |
| 20 | DA (h) | Dynactin subunit 5 | polymer | 222 | 24538.3 | 1 | Pfam (PF21711) UniProt (by SIFTS) (Q9BTE1) | Sus scrofa (Pig) | Dynactin subunit p25 |
| 21 | EA (i) | dynactin pointed end p62 | polymer | 243 | 20698.4 | 1 | Sus scrofa (Pig) | ||
| 22 | FA (j) | p150 | polymer | 52 | 4443.5 | 1 | Sus scrofa (Pig) | ||
| 23 | GA (k) | Dynactin | polymer | 48 | 5400.0 | 1 | UniProt (A0A0J9X292) | Sus scrofa (Pig) | Dynactin subunit 2 |
| 24 | HA (l) | Dynactin | polymer | 71 | 7931.8 | 1 | UniProt (A0A0J9X293) Pfam (PF04912) | Sus scrofa (Pig) | Dynactin subunit 2 |
| 25 | IA (m) | Dynactin | polymer | 31 | 3019.3 | 1 | UniProt (A0A0J9X299) | Sus scrofa (Pig) | |
| 26 | JA (n) | Dynactin | polymer | 20 | 2237.5 | 1 | UniProt (by SIFTS) (A0A0J9X293) | Sus scrofa (Pig) | Dynactin subunit 2 |
| 27 | KA (o) | dynactin p150 | polymer | 53 | 4528.6 | 1 | Sus scrofa (Pig) | ||
| 28 | LA, MA (5, 6) | BICD2N | polymer | 275 | 23421.8 | 2 | Homo sapiens (Human) |
Sequence modifications
G, H, O, P, Q, T, U, W: 1 - 376 (UniProt: F2Z5G5)
V: 3 - 375 (UniProt: I3LVD5)
Z: 2 - 277 (UniProt: D2JYW4)
| PDB | External Database | Details |
|---|---|---|
| Glu 97 | Asp 97 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -20 | - | initiating methionine |
| Ser -19 | - | expression tag |
| Val -18 | - | expression tag |
| Arg -17 | - | expression tag |
| Ser -16 | - | expression tag |
| Ala -15 | - | expression tag |
| Arg -14 | - | expression tag |
| Arg -13 | - | expression tag |
| Ala -12 | - | expression tag |
| Ser -11 | - | expression tag |
| Ala -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Ala -8 | - | expression tag |
| Glu -7 | - | expression tag |
| Ala -6 | - | expression tag |
| Glu -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Gln -2 | - | expression tag |
| Thr -1 | - | expression tag |
| Met 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Asp 2 | - | expression tag |
| Val 10 | Ile 10 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Met -15 | - | initiating methionine |
| Asp -14 | - | expression tag |
| Thr -13 | - | expression tag |
| Glu -12 | - | expression tag |
| Leu -11 | - | expression tag |
| Ala -10 | - | expression tag |
| Ser -9 | - | expression tag |
| Pro -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Pro -6 | - | expression tag |
| Leu -5 | - | expression tag |
| Leu -4 | - | expression tag |
| Leu -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Lys -1 | - | expression tag |
| Tyr 0 | - | expression tag |
| Arg 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 39 |
| Total formula weight | 1095055.1 | |
| All* | Total formula weight | 1095055.1 |
