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5NW4

Human cytoplasmic dynein-1 bound to dynactin and an N-terminal construct of BICD2

Functional Information from GO Data
ChainGOidnamespacecontents
g0000775cellular_componentchromosome, centromeric region
g0000776cellular_componentkinetochore
g0005694cellular_componentchromosome
g0005737cellular_componentcytoplasm
g0005856cellular_componentcytoskeleton
g0005869cellular_componentdynactin complex
g0007052biological_processmitotic spindle organization
g0070840molecular_functiondynein complex binding
h0000775cellular_componentchromosome, centromeric region
h0000776cellular_componentkinetochore
h0003281biological_processventricular septum development
h0005515molecular_functionprotein binding
h0005654cellular_componentnucleoplasm
h0005694cellular_componentchromosome
h0005737cellular_componentcytoplasm
h0005813cellular_componentcentrosome
h0005829cellular_componentcytosol
h0005856cellular_componentcytoskeleton
h0005869cellular_componentdynactin complex
h0031965cellular_componentnuclear membrane
h0035904biological_processaorta development
h0060976biological_processcoronary vasculature development
l0005737cellular_componentcytoplasm
l0005813cellular_componentcentrosome
l0005869cellular_componentdynactin complex
l0007017biological_processmicrotubule-based process
l0007052biological_processmitotic spindle organization
l0030286cellular_componentdynein complex
X0005737cellular_componentcytoplasm
X0005856cellular_componentcytoskeleton
X0005869cellular_componentdynactin complex
X0098958biological_processretrograde axonal transport of mitochondrion
X1904115cellular_componentaxon cytoplasm
Y0003779molecular_functionactin binding
Y0005737cellular_componentcytoplasm
Y0005856cellular_componentcytoskeleton
Y0008290cellular_componentF-actin capping protein complex
Y0030036biological_processactin cytoskeleton organization
Y0030479cellular_componentactin cortical patch
Y0051015molecular_functionactin filament binding
Y0051016biological_processbarbed-end actin filament capping
Y0051693biological_processactin filament capping
Z0000902biological_processcell morphogenesis
Z0003779molecular_functionactin binding
Z0005737cellular_componentcytoplasm
Z0005856cellular_componentcytoskeleton
Z0008290cellular_componentF-actin capping protein complex
Z0010591biological_processregulation of lamellipodium assembly
Z0030036biological_processactin cytoskeleton organization
Z0051015molecular_functionactin filament binding
Z0051016biological_processbarbed-end actin filament capping
Z0051490biological_processnegative regulation of filopodium assembly
Z0051693biological_processactin filament capping
Functional Information from PROSITE/UniProt
site_idPS00231
Number of Residues6
DetailsF_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD
ChainResidueDetails
ZCYS62-ASP67

site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
VTYR53-GLY63

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WISKqEYDE
ChainResidueDetails
VTRP356-GLU364
GTRP357-GLU365

site_idPS00748
Number of Residues9
DetailsF_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV
ChainResidueDetails
YVAL196-VAL204

site_idPS00749
Number of Residues11
DetailsF_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR
ChainResidueDetails
YLYS256-ARG266

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkaNR
ChainResidueDetails
VLEU104-ARG116
GLEU109-ARG121

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378
ChainResidueDetails
hMET1
HMET1
OMET1
PMET1
QMET1
TMET1
UMET1
WMET1

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P52907
ChainResidueDetails
YSER9

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P52907
ChainResidueDetails
YLYS19
YLYS97

222415

PDB entries from 2024-07-10

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