5NVM

Crystal structure of the human 4EHP-GIGYF2 complex lacking the auxiliary sequences

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	Eukaryotic translation initiation factor 4E type 2	polymer	189	21979.1	2	UniProt (O60573) Pfam (PF01652)	Homo sapiens (Human)	eIF4E type 2,Eukaryotic translation initiation factor 4E homologous protein,Eukaryotic translation initiation factor 4E-like 3,eIF4E-like protein 4E-LP,mRNA cap-binding protein 4EHP,h4EHP,mRNA cap-binding protein type 3
2	B, D (B, D)	GRB10-interacting GYF protein 2	polymer	42	5018.9	2	UniProt (Q6Y7W6)	Homo sapiens (Human)	PERQ amino acid-rich with GYF domain-containing protein 2,Trinucleotide repeat-containing gene 15 protein
3	E, F, G, H (A, B, C, D)	PHOSPHATE ION	non-polymer		95.0	4	Chemie (PO4)
4	I, J, K, L (A, B, C, D)	water	water		18.0	130	Chemie (HOH)

Sequence modifications

A, C: 52 - 234 (UniProt: O60573)

PDB	External Database	Details
Gly 46	-	expression tag
Pro 47	-	expression tag
His 48	-	expression tag
Met 49	-	expression tag
Leu 50	-	expression tag
Glu 51	-	expression tag

B, D: 35 - 72 (UniProt: Q6Y7W6)

PDB	External Database	Details
Gly 31	-	expression tag
Pro 32	-	expression tag
His 33	-	expression tag
Met 34	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	53996.0
Non-Polymers*	Number of molecules	4
	Total formula weight	379.9
All*	Total formula weight	54375.9

*Water molecules are not included.