5NTI
Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nuclear receptor ROR-gamma | polymer | 257 | 29739.3 | 4 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | E, F, G, H (P, Q, R, S) | ASN-SER-HIS-GLN-LYS-VAL-THR-LEU-LEU-GLN-LEU-LEU-LEU-GLY-HIS-LYS-ASN-GLU-GLU-ASN | polymer | 20 | 2319.6 | 4 | UniProt (by SIFTS) (P48552) | Homo sapiens (Human) | Nuclear factor RIP140, Receptor-interacting protein 140 |
| 3 | I, J, K, L (A, B, C, D) | CHOLEST-5-EN-3-YL HYDROGEN SULFATE | non-polymer | 466.7 | 4 | Chemie (C3S) PubChem (18631913) PubChem (18637921) PubChem (25055661) PubChem (34174273) PubChem (44359124) PubChem (65076) PubChem (46936278) PubChem (52934309) PubChem (53683001) PubChem (34174265) PubChem (86318757) PubChem (86318759) PubChem (86318761) PubChem (4259412) PubChem (86310857) PubChem (87292651) PubChem (124301052) PubChem (99569635) PubChem (117705488) PubChem (122130877) PubChem (9847391) PubChem (123134861) PubChem (124225017) PubChem (124225018) PubChem (124225019) PubChem (11969852) PubChem (14189346) PubChem (124904518) PubChem (124904519) PubChem (146156788) PubChem (146460988) PubChem (131697794) PubChem (137705228) PubChem (139468493) PubChem (146663698) PubChem (163452773) PubChem (169650022) | |||
| 4 | M, N, O, P, Q... (A, B, C, D, P...) | water | water | 18.0 | 536 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 263 - 518 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 262 | - | expression tag |
| Ser 455 | Cys 455 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 128235.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1866.9 | |
| All* | Total formula weight | 130102.6 |
