5NTI
Structural states of RORgt: X-ray elucidation of molecular mechanisms and binding interactions for natural and synthetic compounds
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Nuclear receptor ROR-gamma | polymer | 257 | 29739.3 | 4 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | E, F, G, H (P, Q, R, S) | ASN-SER-HIS-GLN-LYS-VAL-THR-LEU-LEU-GLN-LEU-LEU-LEU-GLY-HIS-LYS-ASN-GLU-GLU-ASN | polymer | 20 | 2319.6 | 4 | UniProt (by SIFTS) (P48552) | Homo sapiens (Human) | Nuclear factor RIP140, Receptor-interacting protein 140 |
| 3 | I, J, K, L (A, B, C, D) | CHOLEST-5-EN-3-YL HYDROGEN SULFATE | non-polymer | 466.7 | 4 | Chemie (C3S) | |||
| 4 | M, N, O, P, Q... (A, B, C, D, P...) | water | water | 18.0 | 536 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 263 - 518 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 262 | - | expression tag |
| Ser 455 | Cys 455 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 128235.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1866.9 | |
| All* | Total formula weight | 130102.6 |
