5MVN
X-ray structure of the M205W mutant of GLIC in complex with propofol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E | Proton-gated ion channel | polymer | 317 | 36332.7 | 5 | UniProt (Q7NDN8) Pfam (PF02931) In PDB | Gloeobacter violaceus PCC 7421 | GLIC,Ligand-gated ion channel,LGIC |
| 2 | B, A, C, D, E | ACETATE ION | non-polymer | 59.0 | 10 | Chemie (ACT) | |||
| 3 | C, A, D, B, E | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 15 | Chemie (PLC) | |||
| 4 | C, A, D, B, E | CHLORIDE ION | non-polymer | 35.5 | 7 | Chemie (CL) | |||
| 5 | C, A, D, B, E | SODIUM ION | non-polymer | 23.0 | 6 | Chemie (NA) | |||
| 6 | C, A, D, B, E | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 6 | Chemie (LMT) | |||
| 7 | E, B, C, D | 2,6-BIS(1-METHYLETHYL)PHENOL | non-polymer | 178.3 | 4 | Chemie (PFL) | |||
| 8 | water | water | 18.0 | 28 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 317 (UniProt: Q7NDN8)
| PDB | External Database | Details |
|---|---|---|
| Trp 205 | Met 247 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 181663.7 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 14095.8 | |
| All* | Total formula weight | 195759.5 |
