5MVM

X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol

Replaces:  4HFC

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E	Proton-gated ion channel	polymer	317	36158.6	5	UniProt (Q7NDN8) Pfam (PF02931) In PDB	Gloeobacter violaceus PCC 7421	GLIC,Ligand-gated ion channel,LGIC
2	A, C, D, B, E	DODECYL-BETA-D-MALTOSIDE	non-polymer		510.6	6	Chemie (LMT)
3	C, A, D, B, E	ACETATE ION	non-polymer		59.0	10	Chemie (ACT)
4	C, A, D, B, E	CHLORIDE ION	non-polymer		35.5	5	Chemie (CL)
5	E, C, A, D, B	SODIUM ION	non-polymer		23.0	7	Chemie (NA)
6	C, A, D, B, E	DIUNDECYL PHOSPHATIDYL CHOLINE	non-polymer		622.8	15	Chemie (PLC)
7	C, A, B, E	2,6-BIS(1-METHYLETHYL)PHENOL	non-polymer		178.3	5	Chemie (PFL)
8		water	water		18.0	198	Chemie (HOH)

Sequence modifications

A, B, C, D, E: 1 - 317 (UniProt: Q7NDN8)

PDB	External Database	Details
Ala 238	Phe 280	engineered mutation
Ala 239	Asn 281	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	180793.0
Non-Polymers*	Number of molecules	48
	Total formula weight	14226.2
All*	Total formula weight	195019.2

*Water molecules are not included.