5MVM
X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Proton-gated ion channel | polymer | 317 | 36158.6 | 5 | UniProt (Q7NDN8) Pfam (PF02931) | Gloeobacter violaceus PCC 7421 | GLIC,Ligand-gated ion channel,LGIC |
| 2 | F, GA, IA, Q, RA... (A, C, D, B, E) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 6 | Chemie (LMT) | |||
| 3 | AA, G, I, JA, LA... (C, A, D, B, E) | ACETATE ION | non-polymer | 59.0 | 10 | Chemie (ACT) | |||
| 4 | BA, H, KA, S, UA (C, A, D, B, E) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 5 | AB, CA, J, MA, N... (E, C, A, D, B) | SODIUM ION | non-polymer | 23.0 | 7 | Chemie (NA) | |||
| 6 | DA, EA, FA, K, L... (C, A, D, B, E) | DIUNDECYL PHOSPHATIDYL CHOLINE | non-polymer | 622.8 | 15 | Chemie (PLC) | |||
| 7 | HA, O, P, Z, ZA (C, A, B, E) | 2,6-BIS(1-METHYLETHYL)PHENOL | non-polymer | 178.3 | 5 | Chemie (PFL) | |||
| 8 | BB, CB, DB, EB, FB (A, B, C, D, E) | water | water | 18.0 | 198 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 317 (UniProt: Q7NDN8)
| PDB | External Database | Details |
|---|---|---|
| Ala 238 | Phe 280 | engineered mutation |
| Ala 239 | Asn 281 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 180793.0 | |
| Non-Polymers* | Number of molecules | 48 |
| Total formula weight | 14226.2 | |
| All* | Total formula weight | 195019.2 |
