Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5MVM

X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue LMT A 501

Chain	Residue
A	ILE240
A	HOH617
B	THR244
E	LMT401

site_id	AC2
Number of Residues	4
Details	binding site for residue ACT A 502

Chain	Residue
A	ILE73
A	PRO74
A	ILE76
A	ARG85

site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 503

Chain	Residue
A	ARG85
A	HOH627
A	PHE78

site_id	AC4
Number of Residues	5
Details	binding site for residue ACT A 504

Chain	Residue
A	ARG77
A	ILE131
A	GLU181
E	PHE42
E	ARG105

site_id	AC5
Number of Residues	3
Details	binding site for residue NA A 505

Chain	Residue
A	PRO68
A	ILE71
A	ILE73

site_id	AC6
Number of Residues	7
Details	binding site for residue PLC A 506

Chain	Residue
A	ARG118
A	PHE121
A	TYR194
A	ILE202
A	TYR254
A	ASN307
A	PHE315

site_id	AC7
Number of Residues	5
Details	binding site for residue PLC A 507

Chain	Residue
A	THR214
A	TRP217
B	THR274
B	VAL275
B	TYR278

site_id	AC8
Number of Residues	1
Details	binding site for residue NA A 509

Chain	Residue
B	THR226

site_id	AC9
Number of Residues	11
Details	binding site for residue PFL A 510

Chain	Residue
A	ILE236
A	ALA239
A	ILE240
A	GLU243
A	TYR263
A	HOH629
E	ASN200
E	ILE201
E	PRO204
E	ALA238
E	HOH524

site_id	AD1
Number of Residues	9
Details	binding site for residue PFL A 511

Chain	Residue
A	ASN200
A	ILE201
A	PRO204
A	ALA238
B	ILE236
B	ALA239
B	ILE240
B	GLU243
B	TYR263

site_id	AD2
Number of Residues	3
Details	binding site for residue LMT B 501

Chain	Residue
A	ALA237
B	ALA237
E	LMT401

site_id	AD3
Number of Residues	6
Details	binding site for residue ACT B 502

Chain	Residue
B	LEU45
B	ILE73
B	PRO74
B	ILE76
B	ARG85
B	TYR102

site_id	AD4
Number of Residues	3
Details	binding site for residue CL B 503

Chain	Residue
B	ALA84
B	ARG85
B	HOH627

site_id	AD5
Number of Residues	5
Details	binding site for residue ACT B 504

Chain	Residue
A	PHE42
A	ARG105
B	ARG77
B	ILE131
B	GLU181

site_id	AD6
Number of Residues	2
Details	binding site for residue NA B 505

Chain	Residue
B	PRO68
B	ILE71

site_id	AD7
Number of Residues	6
Details	binding site for residue PLC B 506

Chain	Residue
B	ARG118
B	PHE121
B	TYR254
B	ASN307
B	PHE315
B	PLC508

site_id	AD8
Number of Residues	4
Details	binding site for residue PLC B 507

Chain	Residue
B	THR214
B	TRP217
C	VAL275
C	TYR278

site_id	AD9
Number of Residues	1
Details	binding site for residue PLC B 508

Chain	Residue
B	PLC506

site_id	AE1
Number of Residues	5
Details	binding site for residue ACT B 509

Chain	Residue
B	PHE42
B	ARG105
C	ARG77
C	ILE131
C	GLU181

site_id	AE2
Number of Residues	6
Details	binding site for residue PFL B 510

Chain	Residue
B	ASN200
B	ILE201
B	MET205
B	ALA238
B	LEU241
C	TYR263

site_id	AE3
Number of Residues	4
Details	binding site for residue ACT C 401

Chain	Residue
C	PRO74
C	ILE76
C	ARG85
C	TYR102

site_id	AE4
Number of Residues	2
Details	binding site for residue CL C 402

Chain	Residue
C	PHE78
C	ARG85

site_id	AE5
Number of Residues	2
Details	binding site for residue NA C 403

Chain	Residue
C	PRO68
C	ILE71

site_id	AE6
Number of Residues	7
Details	binding site for residue PLC C 404

Chain	Residue
C	ARG118
C	PHE121
C	ILE202
C	TYR254
C	ASN307
C	PLC406
C	HOH516

site_id	AE7
Number of Residues	4
Details	binding site for residue PLC C 405

Chain	Residue
C	THR214
C	TRP217
D	VAL275
D	TYR278

site_id	AE8
Number of Residues	1
Details	binding site for residue PLC C 406

Chain	Residue
C	PLC404

site_id	AE9
Number of Residues	3
Details	binding site for residue LMT C 407

Chain	Residue
C	ALA237
C	ILE240
E	LMT401

site_id	AF1
Number of Residues	10
Details	binding site for residue PFL C 408

Chain	Residue
C	ASN200
C	ILE201
C	ALA238
C	LEU241
C	HOH518
D	ILE236
D	ALA239
D	ILE240
D	GLU243
D	TYR263

site_id	AF2
Number of Residues	1
Details	binding site for residue LMT D 401

Chain	Residue
D	ALA237

site_id	AF3
Number of Residues	5
Details	binding site for residue ACT D 402

Chain	Residue
D	ILE73
D	PRO74
D	ILE76
D	ARG85
D	TYR102

site_id	AF4
Number of Residues	1
Details	binding site for residue CL D 403

Chain	Residue
D	PHE78

site_id	AF5
Number of Residues	5
Details	binding site for residue ACT D 404

Chain	Residue
C	PHE42
C	ARG105
D	ARG77
D	ILE131
D	GLU181

site_id	AF6
Number of Residues	3
Details	binding site for residue NA D 405

Chain	Residue
D	PRO68
D	ILE71
D	ILE73

site_id	AF7
Number of Residues	7
Details	binding site for residue PLC D 406

Chain	Residue
D	ARG118
D	PHE121
D	TYR194
D	TYR254
D	ASN307
D	PHE315
D	PLC408

site_id	AF8
Number of Residues	4
Details	binding site for residue PLC D 407

Chain	Residue
D	THR214
D	TRP217
E	VAL275
E	TYR278

site_id	AF9
Number of Residues	1
Details	binding site for residue PLC D 408

Chain	Residue
D	PLC406

site_id	AG1
Number of Residues	4
Details	binding site for residue ACT D 409

Chain	Residue
D	PHE42
D	ARG105
E	ILE131
E	GLU181

site_id	AG2
Number of Residues	4
Details	binding site for residue LMT E 401

Chain	Residue
A	LMT501
B	LMT501
C	LMT407
E	LMT402

site_id	AG3
Number of Residues	4
Details	binding site for residue LMT E 402

Chain	Residue
A	THR244
E	ILE240
E	ASN245
E	LMT401

site_id	AG4
Number of Residues	6
Details	binding site for residue ACT E 403

Chain	Residue
E	LEU45
E	ILE73
E	PRO74
E	ILE76
E	ARG77
E	ARG85

site_id	AG5
Number of Residues	1
Details	binding site for residue CL E 404

Chain	Residue
E	PHE78

site_id	AG6
Number of Residues	1
Details	binding site for residue NA E 405

Chain	Residue
E	GLU69

site_id	AG7
Number of Residues	7
Details	binding site for residue PLC E 406

Chain	Residue
E	ARG118
E	PHE121
E	TYR194
E	ILE202
E	TYR254
E	ASN307
E	PHE315

site_id	AG8
Number of Residues	6
Details	binding site for residue PLC E 407

Chain	Residue
A	ILE271
A	VAL275
A	TYR278
E	PHE210
E	THR214
E	TRP217

site_id	AG9
Number of Residues	10
Details	binding site for residue PFL E 409

Chain	Residue
D	ASN200
D	ILE201
D	ALA238
D	HOH511
D	HOH538
E	ILE236
E	ALA239
E	ILE240
E	GLU243
E	TYR263

site_id	AH1
Number of Residues	2
Details	binding site for residue NA E 410

Chain	Residue
E	PRO68
E	ILE71

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)