5MVM
X-ray structure of the F14'A -N15'A double mutant of GLIC in complex with propofol
Replaces: 4HFCFunctional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0004888 | molecular_function | transmembrane signaling receptor activity |
E | 0005216 | molecular_function | monoatomic ion channel activity |
E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
E | 0006811 | biological_process | monoatomic ion transport |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue LMT A 501 |
Chain | Residue |
A | ILE240 |
A | HOH617 |
B | THR244 |
E | LMT401 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ACT A 502 |
Chain | Residue |
A | ILE73 |
A | PRO74 |
A | ILE76 |
A | ARG85 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CL A 503 |
Chain | Residue |
A | ARG85 |
A | HOH627 |
A | PHE78 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue ACT A 504 |
Chain | Residue |
A | ARG77 |
A | ILE131 |
A | GLU181 |
E | PHE42 |
E | ARG105 |
site_id | AC5 |
Number of Residues | 3 |
Details | binding site for residue NA A 505 |
Chain | Residue |
A | PRO68 |
A | ILE71 |
A | ILE73 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue PLC A 506 |
Chain | Residue |
A | ARG118 |
A | PHE121 |
A | TYR194 |
A | ILE202 |
A | TYR254 |
A | ASN307 |
A | PHE315 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue PLC A 507 |
Chain | Residue |
A | THR214 |
A | TRP217 |
B | THR274 |
B | VAL275 |
B | TYR278 |
site_id | AC8 |
Number of Residues | 1 |
Details | binding site for residue NA A 509 |
Chain | Residue |
B | THR226 |
site_id | AC9 |
Number of Residues | 11 |
Details | binding site for residue PFL A 510 |
Chain | Residue |
A | ILE236 |
A | ALA239 |
A | ILE240 |
A | GLU243 |
A | TYR263 |
A | HOH629 |
E | ASN200 |
E | ILE201 |
E | PRO204 |
E | ALA238 |
E | HOH524 |
site_id | AD1 |
Number of Residues | 9 |
Details | binding site for residue PFL A 511 |
Chain | Residue |
A | ASN200 |
A | ILE201 |
A | PRO204 |
A | ALA238 |
B | ILE236 |
B | ALA239 |
B | ILE240 |
B | GLU243 |
B | TYR263 |
site_id | AD2 |
Number of Residues | 3 |
Details | binding site for residue LMT B 501 |
Chain | Residue |
A | ALA237 |
B | ALA237 |
E | LMT401 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue ACT B 502 |
Chain | Residue |
B | LEU45 |
B | ILE73 |
B | PRO74 |
B | ILE76 |
B | ARG85 |
B | TYR102 |
site_id | AD4 |
Number of Residues | 3 |
Details | binding site for residue CL B 503 |
Chain | Residue |
B | ALA84 |
B | ARG85 |
B | HOH627 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue ACT B 504 |
Chain | Residue |
A | PHE42 |
A | ARG105 |
B | ARG77 |
B | ILE131 |
B | GLU181 |
site_id | AD6 |
Number of Residues | 2 |
Details | binding site for residue NA B 505 |
Chain | Residue |
B | PRO68 |
B | ILE71 |
site_id | AD7 |
Number of Residues | 6 |
Details | binding site for residue PLC B 506 |
Chain | Residue |
B | ARG118 |
B | PHE121 |
B | TYR254 |
B | ASN307 |
B | PHE315 |
B | PLC508 |
site_id | AD8 |
Number of Residues | 4 |
Details | binding site for residue PLC B 507 |
Chain | Residue |
B | THR214 |
B | TRP217 |
C | VAL275 |
C | TYR278 |
site_id | AD9 |
Number of Residues | 1 |
Details | binding site for residue PLC B 508 |
Chain | Residue |
B | PLC506 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue ACT B 509 |
Chain | Residue |
B | PHE42 |
B | ARG105 |
C | ARG77 |
C | ILE131 |
C | GLU181 |
site_id | AE2 |
Number of Residues | 6 |
Details | binding site for residue PFL B 510 |
Chain | Residue |
B | ASN200 |
B | ILE201 |
B | MET205 |
B | ALA238 |
B | LEU241 |
C | TYR263 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue ACT C 401 |
Chain | Residue |
C | PRO74 |
C | ILE76 |
C | ARG85 |
C | TYR102 |
site_id | AE4 |
Number of Residues | 2 |
Details | binding site for residue CL C 402 |
Chain | Residue |
C | PHE78 |
C | ARG85 |
site_id | AE5 |
Number of Residues | 2 |
Details | binding site for residue NA C 403 |
Chain | Residue |
C | PRO68 |
C | ILE71 |
site_id | AE6 |
Number of Residues | 7 |
Details | binding site for residue PLC C 404 |
Chain | Residue |
C | ARG118 |
C | PHE121 |
C | ILE202 |
C | TYR254 |
C | ASN307 |
C | PLC406 |
C | HOH516 |
site_id | AE7 |
Number of Residues | 4 |
Details | binding site for residue PLC C 405 |
Chain | Residue |
C | THR214 |
C | TRP217 |
D | VAL275 |
D | TYR278 |
site_id | AE8 |
Number of Residues | 1 |
Details | binding site for residue PLC C 406 |
Chain | Residue |
C | PLC404 |
site_id | AE9 |
Number of Residues | 3 |
Details | binding site for residue LMT C 407 |
Chain | Residue |
C | ALA237 |
C | ILE240 |
E | LMT401 |
site_id | AF1 |
Number of Residues | 10 |
Details | binding site for residue PFL C 408 |
Chain | Residue |
C | ASN200 |
C | ILE201 |
C | ALA238 |
C | LEU241 |
C | HOH518 |
D | ILE236 |
D | ALA239 |
D | ILE240 |
D | GLU243 |
D | TYR263 |
site_id | AF2 |
Number of Residues | 1 |
Details | binding site for residue LMT D 401 |
Chain | Residue |
D | ALA237 |
site_id | AF3 |
Number of Residues | 5 |
Details | binding site for residue ACT D 402 |
Chain | Residue |
D | ILE73 |
D | PRO74 |
D | ILE76 |
D | ARG85 |
D | TYR102 |
site_id | AF4 |
Number of Residues | 1 |
Details | binding site for residue CL D 403 |
Chain | Residue |
D | PHE78 |
site_id | AF5 |
Number of Residues | 5 |
Details | binding site for residue ACT D 404 |
Chain | Residue |
C | PHE42 |
C | ARG105 |
D | ARG77 |
D | ILE131 |
D | GLU181 |
site_id | AF6 |
Number of Residues | 3 |
Details | binding site for residue NA D 405 |
Chain | Residue |
D | PRO68 |
D | ILE71 |
D | ILE73 |
site_id | AF7 |
Number of Residues | 7 |
Details | binding site for residue PLC D 406 |
Chain | Residue |
D | ARG118 |
D | PHE121 |
D | TYR194 |
D | TYR254 |
D | ASN307 |
D | PHE315 |
D | PLC408 |
site_id | AF8 |
Number of Residues | 4 |
Details | binding site for residue PLC D 407 |
Chain | Residue |
D | THR214 |
D | TRP217 |
E | VAL275 |
E | TYR278 |
site_id | AF9 |
Number of Residues | 1 |
Details | binding site for residue PLC D 408 |
Chain | Residue |
D | PLC406 |
site_id | AG1 |
Number of Residues | 4 |
Details | binding site for residue ACT D 409 |
Chain | Residue |
D | PHE42 |
D | ARG105 |
E | ILE131 |
E | GLU181 |
site_id | AG2 |
Number of Residues | 4 |
Details | binding site for residue LMT E 401 |
Chain | Residue |
A | LMT501 |
B | LMT501 |
C | LMT407 |
E | LMT402 |
site_id | AG3 |
Number of Residues | 4 |
Details | binding site for residue LMT E 402 |
Chain | Residue |
A | THR244 |
E | ILE240 |
E | ASN245 |
E | LMT401 |
site_id | AG4 |
Number of Residues | 6 |
Details | binding site for residue ACT E 403 |
Chain | Residue |
E | LEU45 |
E | ILE73 |
E | PRO74 |
E | ILE76 |
E | ARG77 |
E | ARG85 |
site_id | AG5 |
Number of Residues | 1 |
Details | binding site for residue CL E 404 |
Chain | Residue |
E | PHE78 |
site_id | AG6 |
Number of Residues | 1 |
Details | binding site for residue NA E 405 |
Chain | Residue |
E | GLU69 |
site_id | AG7 |
Number of Residues | 7 |
Details | binding site for residue PLC E 406 |
Chain | Residue |
E | ARG118 |
E | PHE121 |
E | TYR194 |
E | ILE202 |
E | TYR254 |
E | ASN307 |
E | PHE315 |
site_id | AG8 |
Number of Residues | 6 |
Details | binding site for residue PLC E 407 |
Chain | Residue |
A | ILE271 |
A | VAL275 |
A | TYR278 |
E | PHE210 |
E | THR214 |
E | TRP217 |
site_id | AG9 |
Number of Residues | 10 |
Details | binding site for residue PFL E 409 |
Chain | Residue |
D | ASN200 |
D | ILE201 |
D | ALA238 |
D | HOH511 |
D | HOH538 |
E | ILE236 |
E | ALA239 |
E | ILE240 |
E | GLU243 |
E | TYR263 |
site_id | AH1 |
Number of Residues | 2 |
Details | binding site for residue NA E 410 |
Chain | Residue |
E | PRO68 |
E | ILE71 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 990 |
Details | TOPO_DOM: Periplasmic => ECO:0000255 |
Chain | Residue | Details |
A | GLN2-GLN193 | |
E | ASN245-MET252 | |
A | ASN245-MET252 | |
B | GLN2-GLN193 | |
B | ASN245-MET252 | |
C | GLN2-GLN193 | |
C | ASN245-MET252 | |
D | GLN2-GLN193 | |
D | ASN245-MET252 | |
E | GLN2-GLN193 |
site_id | SWS_FT_FI2 |
Number of Residues | 530 |
Details | TRANSMEM: Helical |
Chain | Residue | Details |
A | TYR194-PHE216 | |
C | SER220-THR244 | |
C | THR253-VAL281 | |
C | PRO285-PHE317 | |
D | TYR194-PHE216 | |
D | SER220-THR244 | |
D | THR253-VAL281 | |
D | PRO285-PHE317 | |
E | TYR194-PHE216 | |
E | SER220-THR244 | |
E | THR253-VAL281 | |
A | SER220-THR244 | |
E | PRO285-PHE317 | |
A | THR253-VAL281 | |
A | PRO285-PHE317 | |
B | TYR194-PHE216 | |
B | SER220-THR244 | |
B | THR253-VAL281 | |
B | PRO285-PHE317 | |
C | TYR194-PHE216 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | TRP217-THR219 | |
E | GLU282-GLN284 | |
A | GLU282-GLN284 | |
B | TRP217-THR219 | |
B | GLU282-GLN284 | |
C | TRP217-THR219 | |
C | GLU282-GLN284 | |
D | TRP217-THR219 | |
D | GLU282-GLN284 | |
E | TRP217-THR219 |