5MSA
Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Carbonic anhydrase 12 | polymer | 263 | 29917.3 | 4 | UniProt (O43570) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase XII,Carbonic anhydrase XII,CA-XII,Tumor antigen HOM-RCC-3.1.3 |
2 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
3 | A, B, C, D | 2,3,5,6-tetrafluoro-4-(propylsulfanyl)benzenesulfonamide | non-polymer | 303.3 | 4 | Chemie (3TV) | |||
4 | D, A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
5 | D, A, B, C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
6 | D, B | CITRIC ACID | non-polymer | 192.1 | 3 | Chemie (CIT) | |||
7 | water | water | 18.0 | 1442 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 263 (UniProt: O43570)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 119669.3 | |
Non-Polymers* | Number of molecules | 27 |
Total formula weight | 3220.5 | |
All* | Total formula weight | 122889.8 |