5MSA
Crystal structure of human carbonic anhydrase isozyme XII with 2,3,5,6-Tetrafluoro-4-(propylthio)benzenesulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Carbonic anhydrase 12 | polymer | 263 | 29917.3 | 4 | UniProt (O43570) Pfam (PF00194) | Homo sapiens (Human) | Carbonate dehydratase XII,Carbonic anhydrase XII,CA-XII,Tumor antigen HOM-RCC-3.1.3 |
| 2 | E, O, T, Y (A, B, C, D) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 3 | F, P, U, Z (A, B, C, D) | 2,3,5,6-tetrafluoro-4-(propylsulfanyl)benzenesulfonamide | non-polymer | 303.3 | 4 | Chemie (3TV) | |||
| 4 | CA, EA, G, H, I... (D, A, B, C) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 12 | Chemie (EDO) | |||
| 5 | AA, J, R, W (D, A, B, C) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
| 6 | BA, DA, S (D, B) | CITRIC ACID | non-polymer | 192.1 | 3 | Chemie (CIT) | |||
| 7 | FA, GA, HA, IA (A, B, C, D) | water | water | 18.0 | 1442 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 2 - 263 (UniProt: O43570)
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 119669.3 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 3220.5 | |
| All* | Total formula weight | 122889.8 |
