Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004089 | molecular_function | carbonate dehydratase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0004089 | molecular_function | carbonate dehydratase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0004089 | molecular_function | carbonate dehydratase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0004089 | molecular_function | carbonate dehydratase activity |
| D | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 301 |
| Chain | Residue |
| A | HIS91 |
| A | HIS93 |
| A | HIS117 |
| A | 3TV302 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue 3TV A 302 |
| Chain | Residue |
| A | VAL141 |
| A | LEU197 |
| A | THR198 |
| A | THR199 |
| A | PRO200 |
| A | TRP208 |
| A | ZN301 |
| A | HOH428 |
| A | HOH681 |
| A | HOH702 |
| A | HOH745 |
| A | HOH775 |
| A | HIS91 |
| A | HIS93 |
| A | HIS117 |
| A | VAL119 |
| A | LEU139 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | ASN71 |
| A | LEU72 |
| A | THR88 |
| A | HOH419 |
| A | HOH450 |
| A | HOH488 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | THR62 |
| A | ASN63 |
| A | ASN64 |
| A | GLY169 |
| A | GLU171 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | ASP156 |
| A | SER160 |
| A | HOH423 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 306 |
| Chain | Residue |
| A | SER150 |
| A | PHE151 |
| A | HOH421 |
| A | HOH451 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 307 |
| Chain | Residue |
| A | ASP31 |
| A | HIS33 |
| A | SER108 |
| A | GLY109 |
| A | HOH447 |
| A | HOH656 |
| B | GLY109 |
| B | HIS111 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 308 |
| Chain | Residue |
| A | TYR39 |
| A | ALA41 |
| A | SER260 |
| A | HOH406 |
| A | HOH522 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue EDO A 309 |
| Chain | Residue |
| A | LEU53 |
| A | SER54 |
| A | LYS57 |
| A | PHE59 |
| A | PRO73 |
| A | ASP75 |
| A | HOH407 |
| A | HOH425 |
| B | GLN49 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 310 |
| Chain | Residue |
| A | ALA224 |
| A | THR227 |
| A | HOH492 |
| A | HOH619 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | HIS91 |
| B | HIS93 |
| B | HIS117 |
| B | 3TV302 |
| site_id | AD3 |
| Number of Residues | 18 |
| Details | binding site for residue 3TV B 302 |
| Chain | Residue |
| B | GLN89 |
| B | HIS91 |
| B | HIS93 |
| B | HIS117 |
| B | VAL119 |
| B | ALA129 |
| B | SER133 |
| B | LEU139 |
| B | VAL141 |
| B | LEU197 |
| B | THR198 |
| B | THR199 |
| B | PRO200 |
| B | TRP208 |
| B | ZN301 |
| B | CIT305 |
| B | HOH422 |
| B | HOH669 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 303 |
| Chain | Residue |
| B | LEU43 |
| B | THR44 |
| B | LEU46 |
| B | GLY80 |
| B | TYR190 |
| B | ARG192 |
| B | HOH469 |
| B | HOH555 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 304 |
| Chain | Residue |
| B | PHE151 |
| B | PRO153 |
| B | HOH461 |
| B | HOH663 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue CIT B 305 |
| Chain | Residue |
| B | ASN64 |
| B | LYS69 |
| B | GLN89 |
| B | 3TV302 |
| B | HOH402 |
| B | HOH406 |
| B | HOH408 |
| B | HOH411 |
| B | HOH422 |
| B | HOH439 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN C 301 |
| Chain | Residue |
| C | HIS91 |
| C | HIS93 |
| C | HIS117 |
| C | 3TV302 |
| site_id | AD8 |
| Number of Residues | 14 |
| Details | binding site for residue 3TV C 302 |
| Chain | Residue |
| C | HIS91 |
| C | HIS93 |
| C | HIS117 |
| C | VAL119 |
| C | ALA129 |
| C | LEU139 |
| C | VAL141 |
| C | LEU197 |
| C | THR198 |
| C | THR199 |
| C | TRP208 |
| C | ZN301 |
| C | HOH632 |
| C | HOH669 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 303 |
| Chain | Residue |
| C | ASN71 |
| C | LEU72 |
| C | THR88 |
| C | HOH444 |
| C | HOH465 |
| C | HOH494 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue PEG C 304 |
| Chain | Residue |
| C | LYS17 |
| C | LYS18 |
| C | PRO20 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO C 305 |
| Chain | Residue |
| A | GLN82 |
| C | GLU220 |
| C | LEU223 |
| C | ALA224 |
| C | THR227 |
| C | HOH421 |
| C | HOH426 |
| C | HOH428 |
| site_id | AE3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 301 |
| Chain | Residue |
| D | HIS91 |
| D | HIS93 |
| D | HIS117 |
| D | 3TV302 |
| site_id | AE4 |
| Number of Residues | 17 |
| Details | binding site for residue 3TV D 302 |
| Chain | Residue |
| D | GLN89 |
| D | HIS91 |
| D | HIS93 |
| D | HIS117 |
| D | VAL119 |
| D | SER133 |
| D | LEU139 |
| D | VAL141 |
| D | LEU197 |
| D | THR198 |
| D | THR199 |
| D | PRO200 |
| D | TRP208 |
| D | ZN301 |
| D | CIT306 |
| D | HOH473 |
| D | HOH488 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue PEG D 303 |
| Chain | Residue |
| D | THR62 |
| D | LYS168 |
| D | GLY169 |
| D | HIS233 |
| D | HOH463 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue CIT D 304 |
| Chain | Residue |
| D | SER133 |
| D | ASN134 |
| D | PRO201 |
| D | ASN203 |
| D | HOH401 |
| D | HOH404 |
| D | HOH414 |
| D | HOH488 |
| site_id | AE7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 305 |
| site_id | AE8 |
| Number of Residues | 10 |
| Details | binding site for residue CIT D 306 |
| Chain | Residue |
| D | ASN64 |
| D | LYS69 |
| D | GLN89 |
| D | 3TV302 |
| D | HOH405 |
| D | HOH419 |
| D | HOH447 |
| D | HOH463 |
| D | HOH481 |
| D | HOH650 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 307 |
| Chain | Residue |
| A | GLU171 |
| A | PHE173 |
| D | HIS164 |
| D | ALA172 |
| D | PHE173 |
| D | HOH472 |
Functional Information from PROSITE/UniProt
| site_id | PS00162 |
| Number of Residues | 17 |
| Details | ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVsgqhFaaELHIV |
| Chain | Residue | Details |
| A | SER103-VAL119 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11493685","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P00918","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 259 |
| Details | Domain: {"description":"Alpha-carbonic anhydrase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01134","evidenceCode":"ECO:0000255"}]} |
