5MLS
Thrombin Mutant A190S in complex with (S)-1-(D-phenylalanyl)-N-(3-chlorobenzyl)pyrrolidine-2-carboxamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Thrombin light chain | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (Human) | Coagulation factor II |
| 2 | B (H) | Thrombin heavy chain | polymer | 259 | 29796.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (Human) | Coagulation factor II |
| 3 | C (D) | Hirudin variant-2 | polymer | 12 | 1548.6 | 1 | UniProt (P09945) | Hirudo medicinalis | |
| 4 | D (H) | D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide | non-polymer | 385.9 | 1 | BIRD (PRD_000593) Chemie (22U) | |||
| 5 | E (H) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 6 | F (H) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) | |||
| 7 | G, H, I, J, K... (H) | GLYCEROL | non-polymer | 92.1 | 6 | Chemie (GOL) | |||
| 8 | M, N (H) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 9 | O, P, Q (L, H, D) | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
H: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ser 190 | Ala 563 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 35441.3 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1157.5 | |
| All* | Total formula weight | 36598.9 |
