5M8S
Crystal structure of human tyrosinase related protein 1 mutant (T391V-R374S-Y362F) in complex with phenylthiourea (PTU)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | 5,6-dihydroxyindole-2-carboxylic acid oxidase | polymer | 446 | 50531.2 | 4 | UniProt (P17643) Pfam (PF00264) In PDB | Homo sapiens (Human) | DHICA oxidase,Catalase B,Glycoprotein 75,Melanoma antigen gp75,Tyrosinase-related protein 1,TRP1 |
2 | E, H, P | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 3 | In PDB GlyTouCan (G21290RB) | |||
3 | F, G, J, L, N... | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 8 | In PDB GlyTouCan (G42666HT) | |||
4 | I | alpha-D-mannopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 383.3 | 1 | In PDB GlyTouCan (G87612PG) | |||
5 | K | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 1 | In PDB GlyTouCan (G64181RO) | |||
6 | M | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
7 | Q | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G26032DN) | |||
8 | S | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G21381MC) | |||
9 | C, A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 4 | Chemie (NAG) | |||
10 | C, D, A, B | N-PHENYLTHIOUREA | non-polymer | 152.2 | 4 | Chemie (URS) | |||
11 | B, C, D, A | ZINC ION | non-polymer | 65.4 | 9 | Chemie (ZN) | |||
12 | water | water | 18.0 | 722 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 25 - 470 (UniProt: P17643)
PDB | External Database | Details |
---|---|---|
Phe 362 | Tyr 362 | engineered mutation |
Ser 374 | Arg 374 | engineered mutation |
Val 391 | Thr 391 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 202124.6 | |
Branched | Number of molecules | 16 |
Total formula weight | 8720.1 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 2082.4 | |
All* | Total formula weight | 212927.2 |